Spoštovani kupci!
Zaradi prenove spletne strani in prehoda na OJS spletna prodaja trenutno ne dela. Prosim, če sporočite, kaj bi radi kupili, na prodaja@medrazgl.si. Dopišite vaše ime in priimek, naslov ter način plačila (s predračunom, ob povzetju ali z gotovino, če prezvamete gradivo v živo v prostorih uredištva v času uradnih ur).
Hvala za razumevanje!
MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2015 » 1 » | Archive » Medical field » Fields » Clinical Cases » Archive » Medical field » Fields » Gynecology and Obstetrics »

Acute Intermittent Porphyria in Pregnancy – Case Report

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

Acute intermittent porphyria is a rare inherited disease that is caused by the deficiency of one of the enzymes in the heme synthesis chain. Together with the accelerated metabolism of heme it causes accumulation of neurotoxic precursors. The presentation of acute intermittent porphyria attacks varies as it reflects the impairment of the autonomic, somatic peripheral and central nervous systems. The most common symptoms are abdominal pain, impaired consciousness and neuropathy. Attacks of the disease are caused by several triggering factors, such as infections, stress, starvation, certain medications and drugs and female sex hormones. Due to hormonal changes and other triggering factors, acute intermittent porphyria more frequently deteriorates during pregnancy. Such deteriorations are associated with high maternal and fetal morbidity and mortality. Prognosis can be significantly improved with careful avoidance of triggering factors and early diagnosis and treatment in case of attacks. We present an example of pregnancy management in a patient with known acute intermittent porphyria.

Authors:
Mugerli Sara, Lučovnik Miha, Novak Antolič Živa

Keywords:
acute intermittent porphyria, heme, pregnancy

Cite as:
Med Razgl. 2015; 54 (1): 127–33.
© 2024 Društvo Medicinski razgledi | Na vrh strani / To top ↑