Gallbladder perforation can appear as an acute perforation followed by biliary peritonitis, as subacute perforation with the formation of a pericholecystic abscess, or as a chronic condition leading to cholecysto-enteric fistula formation. It is mainly associated with gallbladder diseases caused by gallstones, although gallstones are not necessarily an essential feature of perforation. Male sex, diabetes mellitus, atherosclerosis, immune system suppression,