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Management of aortic pathology was surgical and invasive until late 1980s. Stent grafts considerably lowered the invasiveness of the procedure for patients, suitable for endovascular management. Today, endovascular management of aorta is feasible in patients with coarctations, aneurysms, pseudoaneurysms, dissections and ruptures if anatomical requirements are met – a healthy neck for stent graft attachment must be present and vital … Preberite več >>

A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected undesirable effects that became apparent only in the post market phase. In spite of the fact that these idiosyncratic drug reactions (IDR) are relatively rare (their incidence is 1 in 10,000–100,000 patients), they can be life-threatening and thus markedly increase the … Preberite več >>

BACKGROUND. Various types of hypothyroidism require different doses of levothyroxine in order to establish euthyroid state. However, previous studies frequently did not define the type of hypothyroidism and the factors influencing the adequacy of treatment. Therefore, the aim of the present study was to evaluate the treatment with levothyroxine in different well-defined types of hypothyroidism in greater detail. METHODS. In … Preberite več >>

BACKGROUNDS. Although head and neck cancers are not among the most frequent ones, they are important public health issue because of high mortality rates and their association with unhealthy lifestyle. In this paper, we present key epidemiological data, which represent the basis for efficient public health interventions. METHODS. We used incidence and mortality data for head and neck cancers (C00–C14, … Preberite več >>

In the article we provide an overview of paediatric autonomic dysfunctions. In children, autonomic disorders are often overlooked since they can range from mild, not even by health care specialist recognized problems. Signs and symptoms of dysautonomy can be painful and deteriorating to a child's wellbeing so they must be timely recognized and treated. In children some dysautonomy events can … Preberite več >>

Graves’ disease is an autoimmune thyroid disorder and the most frequent cause of hyperthyroidism in Slovenia. Antithyroid drugs are usually used as the first line of treatment. However, in rare cases they cause agranulocytosis with life-threatening neutropenia. We present a case of a patient who was simultaneously diagnosed to have Graves’ disease as well as moderate neutropenia, which was most … Preberite več >>

Tinea faciei is a superficial dermatophyte infection limited to the glabrous skin of the face. It is often seen in pediatric patients. Although the infective organisms and treatments are the same as for other superficial fungal infections, it is frequently misdiagnosed and modified or aggravated by administration of topical or systemic corticosteroids progressing to tinea incognito. We present a case … Preberite več >>

Despite its potential to spread to the brain, metastatic melanoma has been rarely described within the hypothalamic-pituitary axis especially isolated metastases are extremely rare. Metastases to this area most frequently appear in patients with carcinomas of the breast or lungs and are rarely symptomatic, most often patients present with central diabetes insipidus. In the present paper, we report a case … Preberite več >>

Interventional radiology is a part of radiology that uses diagnostic radiologic methodsto guide minimally invasive treatment procedures. The article describes the development of interventional radiology that emerged from diagnostic radiology as a consequence of its creative and fast development in the field of image resolution, the speed of image display, computerised data analysis and display of three-dimensional anatomy. The role … Preberite več >>

Caroli disease was first described in 1958. It is characterized by dilatation of intrahepatic bile ducts. There are two variants of the disease: Caroli disease and Caroli syndrome. In the latter, congenital hepatic fibrosis is present in addition to dilatation of the ducts. The disease is closely associated with autosomal recessive polycystic kidney disease. The main pathological feature is improper … Preberite več >>

Subungual melanoma typically presents with dark, longitudinal lines under the fingernail. The disease is commonly initially misdiagnosed, which leads to delays in correct diagnosis and treatment. Diagnosis is especially difficult in the case of amelanotic subungual melanoma. A histopathological diagnosis is essential; therefore a nail matrix biopsy must be performed. Surgical treatment includes amputation of the distal phalanx of the … Preberite več >>

Intra-abdominal infections encompass all forms of bacterial peritonitis, intra-abdominal abscesses and infections of intra-abdominal organs. They are subcategorized in two groups: uncomplicated and complicated. Complicated infections often result in peritonitis, therefore,
source control requires surgical management, supplemented by antibiotics and supportive therapy. In most severe cases, abdominal sepsis occurs; this may be of intraperitoneal or extraperitoneal origin. For patients with … Preberite več >>

Commonly used metallic osteosynthetic materials include titanium alloys, stainless steels and cobalt-chromium-based alloys. As a result of high modulus of elasticity of metal implants versus bone, the implant compensates a large part of the mechanical stresses applied to the bone, which leads to bone resorption. A second operation is often necessary to remove the implants. Scientists developed new materials, which … Preberite več >>

Mitral regurgitation is defined as a systolic retrograde blood flow from the left ventricle to the left atrium. Moderate or severe mitral regurgitation can be found in 10% of people older than 75 years. It is treated surgically, usually by valvuloplasty. Patients treated by medical treatment alone have a poor prognosis. Percutaneous treatment is becoming the treatment of choice for … Preberite več >>

Streptococcus dysgalactiae subsp. equisimilis (group C/G beta-hemolytic streptococcus) is increasingly being recognized as an important bacterial pathogen in humans. It is part of the normal bacterial microbiota of the human skin, upper respiratory, gastrointestinal and genitourinary tract. Under certain conditions it can cause not only superficial skin and soft tissue infections, but also invasive tissue infections, and even life-threatening streptococcal … Preberite več >>

First issue of 2015 was released. It features the following articles:

• Breast Cancer in Female Type 2 Diabetes Mellitus Patients: A Comparison of Pathohistological Characteristics and Stage in Regard to the Type of Treatment for Diabetes Mellitus – Jan Žmuc
• The Use of Biocompatible PolyHIPE Acrylates for Bone Tissue Engineering – Matjaž Deželak, Aljoša Bavec, Miomir Knežević
• Solid Angle Approach