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This review article deals with measures of multimorbidity, which is defined as coexistence of two or more chronic medical conditions in an individual. This is the first Slovenian review of literature, which enables the choice of the most appropriate measure of multimorbidity when looking for a certain outcome in clinical practice or in research. There are many measures of multimorbidity, which are divided into simple and complex. We have included the measures most commonly mentioned in articles of the last five years. This article presents the measures themselves and also their usefulness in clinical practice and research with respect to the outcome of interest. When the outcome of interest is the quality of life, the most appropriate measure is the number of chronic diseases; for predicting health care utilization the number of drugs prescribed; and for estimating the costs the Adjusted Clinical Groups, the Charlson index and the number of drugs prescribed are equally suitable. When assessing mortality, the Charlson index performs best.