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The gastrinoma was first described by the surgeons Zollinger and Ellison in 1955. The basic characteristics of this disease include an endocrine gastrin-secreting tumor of the gastrointestinal tract, gastric hypersecretion and recurrent gastric, duodenal and jejunal ulcers. The author reports on a 49-year-old female patient in whom a duodenal ulcer and two liver tumors, 10 and 6 cm in diameter, involving the right and the left lobe, respectively, were diagnosed in 1982. A liver biopsy specimen, obtained during explorative laparotomy, was defined histologically as a metastatic small-cell ephitelial tumor with an organoid endocrine pattern. Its morphological pattern was that of a tumor of APUD series. A gatrinoma was verified by immunohistochemical staining. Serum gastrin levels exceeded the normal range by 10 times. The patient refused any further treatment. In the following years, she received several conservative treatments for sequelae of her ulcer disease. For the past three years she has been treated on an out-patient basis, mostly for chronic diarrhea.