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Ticks are well-known vectors of numerous diseases caused by bacteria, viruses and protozoa. In the recent years, the incidence of these illnesses has increased worldwide. Tick-borne meningoencephalitis and Lyme borreliosis are endemic in Slovenia. The authors review the latest findings in epidemiology, pathogenesis, clinical picture and treatment of tick-borne diseases, and stress their significance and the risk of acquiring these diseases in Slovenia.