{"id":10164,"date":"2017-12-08T11:33:19","date_gmt":"2017-12-08T10:33:19","guid":{"rendered":"http:\/\/medrazgl.si\/en\/?p=10164"},"modified":"2018-05-06T10:08:37","modified_gmt":"2018-05-06T08:08:37","slug":"treatment-with-magnesium-sulphate-for-cerebral-palsy-prevention-in-preterm-birth-a-literature-review-and-protocol-presentation","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/treatment-with-magnesium-sulphate-for-cerebral-palsy-prevention-in-preterm-birth-a-literature-review-and-protocol-presentation\/","title":{"rendered":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation"},"content":{"rendered":"<p>Cerebral palsy is a group of movement and posture disorders sometimes associated with other neurological deficits. It represents a significant decrease in the patients\u2019 quality of life and a substantial economic burden. The main risk factors for cerebral palsy are preterm birth and low birth weight. Both factors increase the risk for periventriculary\u00a0leucomalacia, which is the most important pathomorphological change found in the brain of children with cerebral palsy. Magnesium sulphate has two principal roles in obstetrics. It is used for prevention of eclamptic attacks in women with pre-eclampsia and for tocolysis. Several randomized trials and meta-analyzes have demonstrated that treatment with magnesium sulphate in pregnant women with threatened preterm delivery reduces the risk of cerebral palsy in their children, most likely through the combined anti-ischemic and anti-inflammatory effect. In Slovenia there are no official recommendations for the neuroprotective use of MgSO4 in preterm birth. The purpose of this article is to present a proposal for such recommendations and to review the literature upon which these recommendations are based.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cerebral palsy is a group of movement and posture disorders sometimes associated with other neurological deficits. It represents a significant decrease in the patients\u2019 quality of life and a substantial economic burden. The main risk factors for cerebral palsy are preterm birth and low birth weight. Both factors increase the risk for periventriculary\u00a0leucomalacia, which is [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[801,421],"tags":[],"class_list":["post-10164","post","type-post","status-publish","format-standard","hentry","category-2-2015-archive","category-gynecology-and-obstetrics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Cerebral palsy is a group of movement and posture disorders sometimes associated with other neurological deficits. It represents a significant decrease in the patients\u2019 quality of life and a substantial economic burden. The main risk factors for cerebral palsy are preterm birth and low birth weight. Both factors increase the risk for periventriculary\u00a0leucomalacia, which is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-08T10:33:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-05-06T08:08:37+00:00\" \/>\n<meta name=\"author\" content=\"Matej Gori\u010dar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Matej Gori\u010dar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/\"},\"author\":{\"name\":\"Matej Gori\u010dar\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\"},\"headline\":\"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation\",\"datePublished\":\"2017-12-08T10:33:19+00:00\",\"dateModified\":\"2018-05-06T08:08:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/\"},\"wordCount\":187,\"commentCount\":0,\"articleSection\":[\"2\",\"Gynecology and Obstetrics\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/\",\"name\":\"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2017-12-08T10:33:19+00:00\",\"dateModified\":\"2018-05-06T08:08:37+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\",\"name\":\"Matej Gori\u010dar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"caption\":\"Matej Gori\u010dar\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/matej-goricar\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/","og_locale":"en_US","og_type":"article","og_title":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi","og_description":"Cerebral palsy is a group of movement and posture disorders sometimes associated with other neurological deficits. It represents a significant decrease in the patients\u2019 quality of life and a substantial economic burden. The main risk factors for cerebral palsy are preterm birth and low birth weight. Both factors increase the risk for periventriculary\u00a0leucomalacia, which is [&hellip;]","og_url":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/","og_site_name":"Dru\u0161tvo Medicinski razgledi","article_published_time":"2017-12-08T10:33:19+00:00","article_modified_time":"2018-05-06T08:08:37+00:00","author":"Matej Gori\u010dar","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Matej Gori\u010dar","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/#article","isPartOf":{"@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/"},"author":{"name":"Matej Gori\u010dar","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca"},"headline":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation","datePublished":"2017-12-08T10:33:19+00:00","dateModified":"2018-05-06T08:08:37+00:00","mainEntityOfPage":{"@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/"},"wordCount":187,"commentCount":0,"articleSection":["2","Gynecology and Obstetrics"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/","url":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/","name":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation - Dru\u0161tvo Medicinski razgledi","isPartOf":{"@id":"https:\/\/medrazgl.si\/#website"},"datePublished":"2017-12-08T10:33:19+00:00","dateModified":"2018-05-06T08:08:37+00:00","author":{"@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca"},"breadcrumb":{"@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medrazgl.si\/zdravljenje-z-magnezijevim-sulfatom-za-preprecevanje-cerebralne-paralize-pri-prezgodnjem-porodu-pregled-literature-in-predstavitev-protokola\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medrazgl.si\/en\/"},{"@type":"ListItem","position":2,"name":"Treatment with Magnesium Sulphate for Cerebral Palsy Prevention in Preterm Birth: A Literature Review and Protocol Presentation"}]},{"@type":"WebSite","@id":"https:\/\/medrazgl.si\/#website","url":"https:\/\/medrazgl.si\/","name":"Dru\u0161tvo Medicinski razgledi","description":"Dru\u0161tvo Medicinski razgledi","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medrazgl.si\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca","name":"Matej Gori\u010dar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","caption":"Matej Gori\u010dar"},"url":"https:\/\/medrazgl.si\/en\/author\/matej-goricar\/"}]}},"_links":{"self":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/10164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/comments?post=10164"}],"version-history":[{"count":0,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/10164\/revisions"}],"wp:attachment":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/media?parent=10164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/categories?post=10164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/tags?post=10164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}