{"id":10643,"date":"2018-03-26T23:49:47","date_gmt":"2018-03-26T21:49:47","guid":{"rendered":"http:\/\/medrazgl.si\/en\/?p=10643"},"modified":"2018-03-26T23:49:47","modified_gmt":"2018-03-26T21:49:47","slug":"extracellular-vesicles-and-their-clinical-potential","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/extracellular-vesicles-and-their-clinical-potential\/","title":{"rendered":"Extracellular Vesicles and their Clinical Potential"},"content":{"rendered":"<p>Extracellular vesicles are a heterogeneous population of membrane vesicles, released from cells both in vivo and in vitro, with an important role in intercellular communication. They have been isolated from a variety of biological samples such as blood, bronchoalveolar lavage, synovial fluid, urine, amniotic fluid, semen, milk, saliva; and from cell cultures of most mammalian cells. Based on their size and the site of formation in the cell, they are classified as exosomes (30\u2013100 nm), microvesicles (100\u20131,000 nm) and apoptotic bodies (1,000\u20135,000 nm). Their protein, nucleic acid (miRNA) and lipid composition reflects the composition ofthe parental cell and depends on the current state ofthe cell. Consequently, the extracellular vesicles are an important source of novel biomarkers for diverse physiological conditions with important diagnostic and prognostic values, especially for disorders of the central nervous system. Researchers also investigate the potential use of extracellular vesicles as targets for diagnostic and therapeutic purposes, but many obstacles still have to be overcome. Due to their great clinical potential, the interest in extracellular vesicle characterization, formation and role increased importantly in recent years, fueling also development of new methods for their isolation and analysis. In the present review, we will describe the types of extracellular vesicles, methods for their isolation and analysis, their biological role and clinical potential.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Extracellular vesicles are a heterogeneous population of membrane vesicles, released from cells both in vivo and in vitro, with an important role in intercellular communication. They have been isolated from a variety of biological samples such as blood, bronchoalveolar lavage, synovial fluid, urine, amniotic fluid, semen, milk, saliva; and from cell cultures of most mammalian [&hellip;]<\/p>\n","protected":false},"author":52,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[804,412,413],"tags":[],"class_list":["post-10643","post","type-post","status-publish","format-standard","hentry","category-1-2016-archive","category-biochemistry","category-cell-biology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Extracellular vesicles are a heterogeneous population of membrane vesicles, released from cells both in vivo and in vitro, with an important role in intercellular communication. They have been isolated from a variety of biological samples such as blood, bronchoalveolar lavage, synovial fluid, urine, amniotic fluid, semen, milk, saliva; and from cell cultures of most mammalian [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2018-03-26T21:49:47+00:00\" \/>\n<meta name=\"author\" content=\"Samo Ro\u0161kar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Samo Ro\u0161kar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/\"},\"author\":{\"name\":\"Samo Ro\u0161kar\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/df9e6d851f1e90c69e5e1756215ac3df\"},\"headline\":\"Extracellular Vesicles and their Clinical Potential\",\"datePublished\":\"2018-03-26T21:49:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/\"},\"wordCount\":216,\"commentCount\":0,\"articleSection\":[\"1\",\"Biochemistry\",\"Cell Biology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/\",\"name\":\"Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2018-03-26T21:49:47+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/df9e6d851f1e90c69e5e1756215ac3df\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Extracellular Vesicles and their Clinical Potential\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/df9e6d851f1e90c69e5e1756215ac3df\",\"name\":\"Samo Ro\u0161kar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g\",\"caption\":\"Samo Ro\u0161kar\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/samo-roskar\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/","og_locale":"en_US","og_type":"article","og_title":"Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi","og_description":"Extracellular vesicles are a heterogeneous population of membrane vesicles, released from cells both in vivo and in vitro, with an important role in intercellular communication. They have been isolated from a variety of biological samples such as blood, bronchoalveolar lavage, synovial fluid, urine, amniotic fluid, semen, milk, saliva; and from cell cultures of most mammalian [&hellip;]","og_url":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/","og_site_name":"Dru\u0161tvo Medicinski razgledi","article_published_time":"2018-03-26T21:49:47+00:00","author":"Samo Ro\u0161kar","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Samo Ro\u0161kar","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/#article","isPartOf":{"@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/"},"author":{"name":"Samo Ro\u0161kar","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/df9e6d851f1e90c69e5e1756215ac3df"},"headline":"Extracellular Vesicles and their Clinical Potential","datePublished":"2018-03-26T21:49:47+00:00","mainEntityOfPage":{"@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/"},"wordCount":216,"commentCount":0,"articleSection":["1","Biochemistry","Cell Biology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/","url":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/","name":"Extracellular Vesicles and their Clinical Potential - Dru\u0161tvo Medicinski razgledi","isPartOf":{"@id":"https:\/\/medrazgl.si\/#website"},"datePublished":"2018-03-26T21:49:47+00:00","author":{"@id":"https:\/\/medrazgl.si\/#\/schema\/person\/df9e6d851f1e90c69e5e1756215ac3df"},"breadcrumb":{"@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medrazgl.si\/zunajcelicni-vezikli-in-njihov-klinicni-potencial\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medrazgl.si\/en\/"},{"@type":"ListItem","position":2,"name":"Extracellular Vesicles and their Clinical Potential"}]},{"@type":"WebSite","@id":"https:\/\/medrazgl.si\/#website","url":"https:\/\/medrazgl.si\/","name":"Dru\u0161tvo Medicinski razgledi","description":"Dru\u0161tvo Medicinski razgledi","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medrazgl.si\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/df9e6d851f1e90c69e5e1756215ac3df","name":"Samo Ro\u0161kar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e26967d2e3508ee09365eacfd0416e52ddbcebf6cd2eab6d87a453c49bc6d2f2?s=96&d=mm&r=g","caption":"Samo Ro\u0161kar"},"url":"https:\/\/medrazgl.si\/en\/author\/samo-roskar\/"}]}},"_links":{"self":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/10643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/comments?post=10643"}],"version-history":[{"count":0,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/10643\/revisions"}],"wp:attachment":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/media?parent=10643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/categories?post=10643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/tags?post=10643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}