{"id":1827,"date":"2013-08-19T16:08:23","date_gmt":"2013-08-19T16:08:23","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=1827"},"modified":"2013-08-19T16:08:23","modified_gmt":"2013-08-19T16:08:23","slug":"desmosomes-are-stable-but-dynamic-cell-junctions","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/desmosomes-are-stable-but-dynamic-cell-junctions\/","title":{"rendered":"Desmosomes are Stable, but Dynamic Cell Junctions"},"content":{"rendered":"<div>\n<p>Desmosomes are the strongest cell junctions. They are especially abundant in tissues such as the epithelium and the cardiac muscle, which are subject to mechanical stress. A desmosome consists of two desmosomal halves, which contain a transmembrane region for intercellular binding and a cytosolic plaque region that anchors intermediate filaments. The intermedi\u00adate filament network in adjacent cells distributes spot loads on the tissue across the entire surface, thereby reducing the risk of tissue injury. The desmosome dynamics are controlled by changes in extracellular Ca<sup>2<\/sup>+ concentrations, phosphorylation of desmosomal proteins and the activity of enzymes which proteolytically cleave desmosome proteins. Splitting of desmo\u00adsomal halves leads to the transport of desmosomal proteins into the lysosomes or non-lysosomal compartments. Desmosomal proteins from de novo synthesis and from cytosolic pools of desmo\u00adsomal proteins enable the assembly of new desmosomes. These dynamic attributes of desmosomes are important prerequisites for the acquisition and maintenance of tissue homeostasis during morphogenesis, embryogenesis and tissue differentiation. Desmosomes are weakened either by autoantibodies, bacterial toxins or mutations, causing desmosomal diseases. In this review, desmosomes are portrayed as stable and dynamic structures that are subject to mechan\u00adical and physiological changes.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Desmosomes are the strongest cell junctions. They are especially abundant in tissues such as the epithelium and the cardiac muscle, which are subject to mechanical stress. A desmosome consists of two desmosomal halves, which contain a transmembrane region for intercellular binding and a cytosolic plaque region that anchors intermediate filaments. The intermedi\u00adate filament network in [&hellip;]<\/p>\n","protected":false},"author":30,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[381,413],"tags":[],"class_list":["post-1827","post","type-post","status-publish","format-standard","hentry","category-3-2008-archive","category-cell-biology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desmosomes are Stable, but Dynamic Cell Junctions - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desmosomes are Stable, but Dynamic Cell Junctions - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Desmosomes are the strongest cell junctions. They are especially abundant in tissues such as the epithelium and the cardiac muscle, which are subject to mechanical stress. A desmosome consists of two desmosomal halves, which contain a transmembrane region for intercellular binding and a cytosolic plaque region that anchors intermediate filaments. The intermedi\u00adate filament network in [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-08-19T16:08:23+00:00\" \/>\n<meta name=\"author\" content=\"\u010crt Zavrnik\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u010crt Zavrnik\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/\"},\"author\":{\"name\":\"\u010crt Zavrnik\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\"},\"headline\":\"Desmosomes are Stable, but Dynamic Cell Junctions\",\"datePublished\":\"2013-08-19T16:08:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/\"},\"wordCount\":200,\"commentCount\":0,\"articleSection\":[\"3\",\"Cell Biology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/\",\"name\":\"Desmosomes are Stable, but Dynamic Cell Junctions - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2013-08-19T16:08:23+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Desmosomes are Stable, but Dynamic Cell Junctions\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\",\"name\":\"\u010crt Zavrnik\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"caption\":\"\u010crt Zavrnik\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/crt-zavrnik\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Desmosomes are Stable, but Dynamic Cell Junctions - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/dezmosomi-stabilni-a-dinamicni-medcelicni-stiki\/","og_locale":"en_US","og_type":"article","og_title":"Desmosomes are Stable, but Dynamic Cell Junctions - Dru\u0161tvo Medicinski razgledi","og_description":"Desmosomes are the strongest cell junctions. 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