{"id":1848,"date":"2013-08-19T16:22:06","date_gmt":"2013-08-19T16:22:06","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=1848"},"modified":"2013-08-19T16:22:13","modified_gmt":"2013-08-19T16:22:13","slug":"cholinesterases-structure-mechanism-and-inhibition-by-natural-and-synthetic-poisons","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/cholinesterases-structure-mechanism-and-inhibition-by-natural-and-synthetic-poisons\/","title":{"rendered":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons"},"content":{"rendered":"<div>\n<p>Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an anchoring, collagen-like peptide. The 3D structure of a monomer shows a buried active site, which is responsible for the effectiveness and specificity of the enzyme, but also for various pseudocooperative phenomena. Due to its important role, acetyl\u00adcholinesterase is a target for various inhibitors, natural as well as artificial ones. Reversible inhibitors prevent substrate accommodation by sterically blocking the active site and the irre\u00adversible ones act as acylating agents that modify the active site serine, the major participant in covalent catalysis. When irreversibly inhibited by potent nerve gases, cholinesterases can be reactivated, unless partial dealkylation of the bound inhibitor has occurred. This particular phe\u00adnomenon, called aging of cholinesterases, along with generalized cytotoxic effect appear to be the cause of organophosphate-induced delayed neurotoxicity in nerve gas poisoned casualties.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an anchoring, collagen-like peptide. The 3D structure of a monomer shows a buried active site, which is responsible for the effectiveness and specificity of the enzyme, [&hellip;]<\/p>\n","protected":false},"author":30,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[381,412],"tags":[],"class_list":["post-1848","post","type-post","status-publish","format-standard","hentry","category-3-2008-archive","category-biochemistry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an anchoring, collagen-like peptide. The 3D structure of a monomer shows a buried active site, which is responsible for the effectiveness and specificity of the enzyme, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-08-19T16:22:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-19T16:22:13+00:00\" \/>\n<meta name=\"author\" content=\"\u010crt Zavrnik\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u010crt Zavrnik\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/\"},\"author\":{\"name\":\"\u010crt Zavrnik\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\"},\"headline\":\"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons\",\"datePublished\":\"2013-08-19T16:22:06+00:00\",\"dateModified\":\"2013-08-19T16:22:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/\"},\"wordCount\":169,\"commentCount\":0,\"articleSection\":[\"3\",\"Biochemistry\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/\",\"name\":\"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2013-08-19T16:22:06+00:00\",\"dateModified\":\"2013-08-19T16:22:13+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/80418a5a6b59976483b5d19fc87a9092\",\"name\":\"\u010crt Zavrnik\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g\",\"caption\":\"\u010crt Zavrnik\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/crt-zavrnik\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/","og_locale":"en_US","og_type":"article","og_title":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi","og_description":"Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an anchoring, collagen-like peptide. The 3D structure of a monomer shows a buried active site, which is responsible for the effectiveness and specificity of the enzyme, [&hellip;]","og_url":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/","og_site_name":"Dru\u0161tvo Medicinski razgledi","article_published_time":"2013-08-19T16:22:06+00:00","article_modified_time":"2013-08-19T16:22:13+00:00","author":"\u010crt Zavrnik","twitter_card":"summary_large_image","twitter_misc":{"Written by":"\u010crt Zavrnik","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/#article","isPartOf":{"@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/"},"author":{"name":"\u010crt Zavrnik","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/80418a5a6b59976483b5d19fc87a9092"},"headline":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons","datePublished":"2013-08-19T16:22:06+00:00","dateModified":"2013-08-19T16:22:13+00:00","mainEntityOfPage":{"@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/"},"wordCount":169,"commentCount":0,"articleSection":["3","Biochemistry"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/","url":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/","name":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons - Dru\u0161tvo Medicinski razgledi","isPartOf":{"@id":"https:\/\/medrazgl.si\/#website"},"datePublished":"2013-08-19T16:22:06+00:00","dateModified":"2013-08-19T16:22:13+00:00","author":{"@id":"https:\/\/medrazgl.si\/#\/schema\/person\/80418a5a6b59976483b5d19fc87a9092"},"breadcrumb":{"@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medrazgl.si\/holin-esteraze-struktura-delovanje-ter-inhibicija-z-naravnimi-in-sinteticnimi-strupi\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medrazgl.si\/en\/"},{"@type":"ListItem","position":2,"name":"Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons"}]},{"@type":"WebSite","@id":"https:\/\/medrazgl.si\/#website","url":"https:\/\/medrazgl.si\/","name":"Dru\u0161tvo Medicinski razgledi","description":"Dru\u0161tvo Medicinski razgledi","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medrazgl.si\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/80418a5a6b59976483b5d19fc87a9092","name":"\u010crt Zavrnik","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b98a6d0f77e61d69dd0d0d8b50dae2e33c8a851e0d1bd0dd468c8998ea95fcc8?s=96&d=mm&r=g","caption":"\u010crt Zavrnik"},"url":"https:\/\/medrazgl.si\/en\/author\/crt-zavrnik\/"}]}},"_links":{"self":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/1848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/comments?post=1848"}],"version-history":[{"count":0,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/1848\/revisions"}],"wp:attachment":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/media?parent=1848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/categories?post=1848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/tags?post=1848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}