{"id":2029,"date":"2013-08-20T12:04:23","date_gmt":"2013-08-20T12:04:23","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=2029"},"modified":"2013-08-20T12:04:23","modified_gmt":"2013-08-20T12:04:23","slug":"insulin-resistance-in-patients-with-polycystic-ovary-syndrome","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/insulin-resistance-in-patients-with-polycystic-ovary-syndrome\/","title":{"rendered":"Insulin Resistance in Patients with Polycystic Ovary Syndrome"},"content":{"rendered":"<div>\n<p>Polycystic ovary syndrome (PCOS) is the most common endocrine disease in fertile women. It is also closely associated with insulin resistance (IR). The purpose of this trial was to inves\u00adtigate the value of clinical and laboratory IR markers routinely used in type 2 diabetes patients (DM2) for the diagnosis of IR in PCOS patients. The goal was to identify the most suitable marker for this condition out of the entire tested panel, which was comprised of HOMA<sub>IR\u00a0<\/sub>intact proinsulin (IP), Sib index and IRIS II score. A total of 50 women with PCOS were recruit\u00aded, along with 20 comparable, healthy women for the control group. HOMA<sub>IR<\/sub> values indi\u00adcating IR (&gt;2) were seen in 26 patients (52%). Patients with IR (based on HOMA<sub>IR<\/sub>) had significantly higher values for BMI (p&lt; 0.001), fasting glucose (4.7 \u00b10.6 vs. 4.2\u00b10.3mmol\/l, p = 0.001), insulin (16.8 \u00b16.2 vs. 7.1 \u00b12.1 pU\/ml, p&lt; 0.001), IP (3.2 \u00b12.0 vs. 1.8 \u00b1 1.0pmol\/l, p = 0.004), triglycerides (1.16 \u00b10.77 vs. 0.80\u00b1 0.35 mmol\/l, p = 0.04), Sib index (6.65 \u00b12.61 vs.\u00a01.7 \u00b111.36, p&lt; 0.001) and IRIS II score (24 \u00b119 vs. 11 \u00b111, p = 0.008). A comparison between the control group and PCOS patients with IR and IS showed significant differences in BMI (p&lt;0.001), triglycerides (p = 0.048), HDL (p&lt; 0.001), fasting glucose (p = 0.004), insulin (p&lt;0.001), IP (p = 0.001), HOMA<sub>ir<\/sub> (p&lt; 0.001), IRIS II score (p = 0.003) and Sib index (p&lt; 0.001). The results of this study indicate that our patients with PCOS did not reach a level of IR that would result in higher IP secretion instead of insulin secretion. Out of the entire tested panel, HOMA<sub>IR<\/sub> score and Sib appeared to be the most suitable markers to assess IR in our patient popula\u00adtion. IRIS II score was less sensitive than HOMA<sub>IR<\/sub> or Sib. None of the patients reached the required IRIS II threshold in DM2 for IR either. Therefore, HOMA<sub>IR<\/sub> and Sib may be suitable index\u00ades for the diagnosis and therapeutic monitoring of IR in this specific patient population.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Polycystic ovary syndrome (PCOS) is the most common endocrine disease in fertile women. It is also closely associated with insulin resistance (IR). The purpose of this trial was to inves\u00adtigate the value of clinical and laboratory IR markers routinely used in type 2 diabetes patients (DM2) for the diagnosis of IR in PCOS patients. The [&hellip;]<\/p>\n","protected":false},"author":30,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[385,426],"tags":[],"class_list":["post-2029","post","type-post","status-publish","format-standard","hentry","category-3-2009-archive","category-internal-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Insulin Resistance in Patients with Polycystic Ovary Syndrome - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/insulinska-rezistenca-pri-bolnicah-s-sindromom-policisticnih-ovarijev\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Insulin Resistance in Patients with Polycystic Ovary Syndrome - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Polycystic ovary syndrome (PCOS) is the most common endocrine disease in fertile women. It is also closely associated with insulin resistance (IR). The purpose of this trial was to inves\u00adtigate the value of clinical and laboratory IR markers routinely used in type 2 diabetes patients (DM2) for the diagnosis of IR in PCOS patients. 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