{"id":2607,"date":"2013-08-26T20:09:25","date_gmt":"2013-08-26T20:09:25","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=2607"},"modified":"2013-08-27T07:42:36","modified_gmt":"2013-08-27T07:42:36","slug":"blood-fibrinolytic-activity-during-anticoagulant-treatment-in-patients-with-deep-vein-thrombosis","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/blood-fibrinolytic-activity-during-anticoagulant-treatment-in-patients-with-deep-vein-thrombosis\/","title":{"rendered":"Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis"},"content":{"rendered":"<div>\n<p align=\"left\">Ninety-nine consecutive patients (42 M, 57 W) with objectively confirmed deep vein throm\u00adbosis (DVT) were included. They were 60 \u00b1 10 years old. Fourty-seven were older than 65 years. In 41 patients DVT was idiopathic. In 20 patients advanced malignancy was present. In other patients DVT developed after surgery or immobilization. In acute DVT patients were treat\u00aded five to seven days with standard heparin combined with warfarin after one to three days of heparin treatment. The prothrombin time, fibrinogen, D-dimer and euglobulin clot lysis time (ECLT) were determined on the first and the seventh day of treatment and three and six months after the acute DVT. For the same anticoagulant effect patients older than 65 years needed a lower doses of warfarin than younger patients. During a long-term treatament with warfarin 47% of the INR in patients without malignancy and only 25% of INR in patients with malignancy were in the therapeutic range (INR 2.0-3.0). Three months after acute DVT sig\u00adnificant prolongation of ECLT was observed. The concentration of D-dimers and fibrinogen decreased in the first three months. Six months after the acute DVT the results were similar to those obtained after three months. During the warfarin tretament we observed prolonga\u00adtion of ECLT and values were back to normal after finishing the warfarin therapy. Therefore, we assume that a long-term warfarin treatment influenced blood fibrinolytic activity.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ninety-nine consecutive patients (42 M, 57 W) with objectively confirmed deep vein throm\u00adbosis (DVT) were included. They were 60 \u00b1 10 years old. Fourty-seven were older than 65 years. In 41 patients DVT was idiopathic. In 20 patients advanced malignancy was present. In other patients DVT developed after surgery or immobilization. In acute DVT patients [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[342,426],"tags":[],"class_list":["post-2607","post","type-post","status-publish","format-standard","hentry","category-3-2000-archive","category-internal-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Ninety-nine consecutive patients (42 M, 57 W) with objectively confirmed deep vein throm\u00adbosis (DVT) were included. They were 60 \u00b1 10 years old. Fourty-seven were older than 65 years. In 41 patients DVT was idiopathic. In 20 patients advanced malignancy was present. In other patients DVT developed after surgery or immobilization. In acute DVT patients [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-08-26T20:09:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-27T07:42:36+00:00\" \/>\n<meta name=\"author\" content=\"O\u017ebej Kun\u0161i\u010d\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"O\u017ebej Kun\u0161i\u010d\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/\"},\"author\":{\"name\":\"O\u017ebej Kun\u0161i\u010d\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/afeabc2cf79a5c40cc7ed495b7961a9a\"},\"headline\":\"Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis\",\"datePublished\":\"2013-08-26T20:09:25+00:00\",\"dateModified\":\"2013-08-27T07:42:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/\"},\"wordCount\":231,\"commentCount\":0,\"articleSection\":[\"3\",\"Internal Medicine\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-dolgotrajnega-antikoagulacijskega-zdravljenja-na-fibroliticno-aktivnost-krvi-pri-bolnikih-z-vensko-trombozo\\\/\",\"name\":\"Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis - 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