{"id":3328,"date":"2013-09-04T16:59:11","date_gmt":"2013-09-04T16:59:11","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3328"},"modified":"2013-09-05T09:00:22","modified_gmt":"2013-09-05T09:00:22","slug":"effect-of-atorvastatin-on-qtc-interval-duration-in-patients-with-heart-failure","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/effect-of-atorvastatin-on-qtc-interval-duration-in-patients-with-heart-failure\/","title":{"rendered":"Effect of Atorvastatin on QTc Interval Duration in Patients with Heart Failure"},"content":{"rendered":"<div>\n<p>Heart failure is related to QTc interval prolongation and changes in the QRS complex. Recently, elevated plasma levels of brain natriuretic peptide (proBNP) is also being recognized as an important prognostic factor of heart failure. Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, statins, might improve general condition and outcome in patients with heart fail\u00adure. We hypothesized that short-term statin treatment shortens QTc interval duration and has beneficial effects in patients with heart failure. Forty-three patients with heart failure of ischemic or nonischemic etiology were randomly divided into two groups. The atorvastatin group (n = 23) received atorvastatin in a dosage of 10 mg\/day for 3 months, while the\u00a0<span style=\"font-size: 13px;line-height: 19px\">control group (n = 20) did not. After 3 months, QTc interval duration in the atorvastatin group was significantly shorter compared to baseline (460.30\u00b1 34.50 vs. 443.35 \u00b1 30.35, p &lt; 0.05), while there were no such changes in the control group. Exercise tolerance was much better in the atorvastatin group after 3 months (309.83 \u00b1 84.46 vs. 341.33 \u00b1 82.21, p &lt; 0.05). A significant shortening (&gt; 10 ms) of the QTc interval in the atorvastatin group was associated with improve\u00adment in exercise capacity. Plasma levels of proBNP and QRS complex duration did not change significantly during the study and neither did they differ between the groups. Short-term atorvastatin treatment shortens QTc interval duration in patients with heart failure and is related to improved exercise capacity, without affecting QRS complex duration or plasma lev\u00adels of proBNP. QTc interval shortening is related to improvements of exercise capacity in patients with heart failure.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Heart failure is related to QTc interval prolongation and changes in the QRS complex. Recently, elevated plasma levels of brain natriuretic peptide (proBNP) is also being recognized as an important prognostic factor of heart failure. Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, statins, might improve general condition and outcome in patients with heart fail\u00adure. We hypothesized that [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[369,407,426],"tags":[],"class_list":["post-3328","post","type-post","status-publish","format-standard","hentry","category-1-2006-archive","category-clinical-research-paper","category-internal-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Effect of Atorvastatin on QTc Interval Duration in Patients with Heart Failure - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of Atorvastatin on QTc Interval Duration in Patients with Heart Failure - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Heart failure is related to QTc interval prolongation and changes in the QRS complex. Recently, elevated plasma levels of brain natriuretic peptide (proBNP) is also being recognized as an important prognostic factor of heart failure. Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, statins, might improve general condition and outcome in patients with heart fail\u00adure. We hypothesized that [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-04T16:59:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-09-05T09:00:22+00:00\" \/>\n<meta name=\"author\" content=\"Anja Kova\u010d\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anja Kova\u010d\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/\"},\"author\":{\"name\":\"Anja Kova\u010d\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/d038976775a5fd248b384c22234676a4\"},\"headline\":\"Effect of Atorvastatin on QTc Interval Duration in Patients with Heart Failure\",\"datePublished\":\"2013-09-04T16:59:11+00:00\",\"dateModified\":\"2013-09-05T09:00:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/\"},\"wordCount\":253,\"commentCount\":0,\"articleSection\":[\"1\",\"Clinical research paper\",\"Internal Medicine\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-atorvastatina-na-trajanje-intervala-qtc-pri-bolnikih-s-srcnim-popuscanjem\\\/\",\"name\":\"Effect of Atorvastatin on QTc Interval Duration in Patients with Heart Failure - 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