{"id":3360,"date":"2013-09-04T18:10:57","date_gmt":"2013-09-04T18:10:57","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3360"},"modified":"2013-09-05T08:52:56","modified_gmt":"2013-09-05T08:52:56","slug":"the-diagnostic-value-of-non-invasive-tests-of-the-helicobacter-pylori-infection-in-the-childhood","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/the-diagnostic-value-of-non-invasive-tests-of-the-helicobacter-pylori-infection-in-the-childhood\/","title":{"rendered":"The Diagnostic Value of Non-invasive Tests of the Helicobacter pylori Infection in the Childhood"},"content":{"rendered":"<div>\n<p>The infection with <em>Helicobacter pylori<\/em>, mostly asymptomatic in children, is also an important factor in the development of intestinal metaplasia and gastric carcinoma in adulthood. In the present article we want to establish whether the noninvasive diagnostic tests of the <em>Helicobacter pylori<\/em> infection could individually and in different combinations be used in every-day paediatric clinical practice. A total of 62 coincidentally chosen children with symp\u00adtoms and signs suspicious of the HP infection were prospectively studied. They underwent four noninvasive diagnostic tests: serology &#8211; specific antibodies IgA and IgG against HP, stool antigen test and 13-C urea breath test. 32 of the patients had their infection confirmed with\u00a0<span style=\"font-size: 13px;line-height: 19px\">the invasive gold standard method. We calculated specificity, sensitivity, positive and nega\u00adtive predictive value and ROC area under the curve for an individual test. We estimated the diagnostic values of test combinations with ROC testing and classic discriminative analysis. Urea breath test compared to HpSA, IgG and IgA has been shown to have the highest diag\u00adnostic value as an individual test. The combination of all four tests has the diagnostic value that is higher than of any of the individual tests. The same applies to combination urea breath test + HpSA or with serology. The results of combination of both serologic tests and combina\u00adtion serology + HpSA turned out to be worse. Urea breath test individually and its combinations with HpSA or serology (IgG, IgA) are clinically applicable as the screening methods for HP infection. The same goes to the combination of all four tests.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The infection with Helicobacter pylori, mostly asymptomatic in children, is also an important factor in the development of intestinal metaplasia and gastric carcinoma in adulthood. In the present article we want to establish whether the noninvasive diagnostic tests of the Helicobacter pylori infection could individually and in different combinations be used in every-day paediatric clinical [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[369,441],"tags":[],"class_list":["post-3360","post","type-post","status-publish","format-standard","hentry","category-1-2006-archive","category-pediatrics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Diagnostic Value of Non-invasive Tests of the Helicobacter pylori Infection in the Childhood - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Diagnostic Value of Non-invasive Tests of the Helicobacter pylori Infection in the Childhood - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"The infection with Helicobacter pylori, mostly asymptomatic in children, is also an important factor in the development of intestinal metaplasia and gastric carcinoma in adulthood. In the present article we want to establish whether the noninvasive diagnostic tests of the Helicobacter pylori infection could individually and in different combinations be used in every-day paediatric clinical [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-04T18:10:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-09-05T08:52:56+00:00\" \/>\n<meta name=\"author\" content=\"Anja Kova\u010d\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anja Kova\u010d\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/\"},\"author\":{\"name\":\"Anja Kova\u010d\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/d038976775a5fd248b384c22234676a4\"},\"headline\":\"The Diagnostic Value of Non-invasive Tests of the Helicobacter pylori Infection in the Childhood\",\"datePublished\":\"2013-09-04T18:10:57+00:00\",\"dateModified\":\"2013-09-05T08:52:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/\"},\"wordCount\":266,\"commentCount\":0,\"articleSection\":[\"1\",\"Pediatrics\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/diagnosticna-vrednost-neinvazivnih-testov-pri-okuzbi-s-helicobacter-pylori-v-otroski-dobi\\\/\",\"name\":\"The Diagnostic Value of Non-invasive Tests of the Helicobacter pylori Infection in the Childhood - 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