{"id":3407,"date":"2013-09-05T07:35:11","date_gmt":"2013-09-05T07:35:11","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3407"},"modified":"2013-09-05T07:35:11","modified_gmt":"2013-09-05T07:35:11","slug":"hereditary-elliptocytosis","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/hereditary-elliptocytosis\/","title":{"rendered":"Hereditary Elliptocytosis"},"content":{"rendered":"
\n

Hereditary elliptocytosis is a clinically, biochemically and genetically heterogeneous group of inherited disorders of red blood cells. It is characterised by the presence of elongated, oval or elliptically shaped erythrocytes on the peripheral blood smear. The elliptocytic pheno\u00adtype has been shown to result from various defects of proteins that constitute membrane skeletal network. This network and molecules that bind it to the lipid bilayer are responsible for the shape of red blood cell and the stability and deformability of its membrane. This article will concentrate on findings about molecular anatomy of erythrocyte membrane and membrane skeleton, mutations of genes for structural proteins of elliptocytic membrane skeleton and functional changes of these proteins and interactions among them, their influences on mechanical properties of the membrane and consequentially on the cellular shape.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Hereditary elliptocytosis is a clinically, biochemically and genetically heterogeneous group of inherited disorders of red blood cells. It is characterised by the presence of elongated, oval or elliptically shaped erythrocytes on the peripheral blood smear. The elliptocytic pheno\u00adtype has been shown to result from various defects of proteins that constitute membrane skeletal network. This network […]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[370,411,426],"tags":[],"class_list":["post-3407","post","type-post","status-publish","format-standard","hentry","category-2-2006-archive","category-biophysics","category-internal-medicine"],"acf":[],"yoast_head":"\nHereditary Elliptocytosis - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/dedna-eliptocitoza\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hereditary Elliptocytosis - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Hereditary elliptocytosis is a clinically, biochemically and genetically heterogeneous group of inherited disorders of red blood cells. It is characterised by the presence of elongated, oval or elliptically shaped erythrocytes on the peripheral blood smear. The elliptocytic pheno\u00adtype has been shown to result from various defects of proteins that constitute membrane skeletal network. This network […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/dedna-eliptocitoza\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-05T07:35:11+00:00\" \/>\n<meta name=\"author\" content=\"Anja Kova\u010d\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anja Kova\u010d\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/\"},\"author\":{\"name\":\"Anja Kova\u010d\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/d038976775a5fd248b384c22234676a4\"},\"headline\":\"Hereditary Elliptocytosis\",\"datePublished\":\"2013-09-05T07:35:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/\"},\"wordCount\":133,\"commentCount\":0,\"articleSection\":[\"2\",\"Biophysics\",\"Internal Medicine\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/\",\"name\":\"Hereditary Elliptocytosis - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2013-09-05T07:35:11+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/d038976775a5fd248b384c22234676a4\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/dedna-eliptocitoza\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hereditary Elliptocytosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/d038976775a5fd248b384c22234676a4\",\"name\":\"Anja Kova\u010d\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c32c83ec58802601921a9b60ec78dcb8c6540a7a25a553ac1ce3b6aceed4863a?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c32c83ec58802601921a9b60ec78dcb8c6540a7a25a553ac1ce3b6aceed4863a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c32c83ec58802601921a9b60ec78dcb8c6540a7a25a553ac1ce3b6aceed4863a?s=96&d=mm&r=g\",\"caption\":\"Anja Kova\u010d\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/anja-kovac\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hereditary Elliptocytosis - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/dedna-eliptocitoza\/","og_locale":"en_US","og_type":"article","og_title":"Hereditary Elliptocytosis - Dru\u0161tvo Medicinski razgledi","og_description":"Hereditary elliptocytosis is a clinically, biochemically and genetically heterogeneous group of inherited disorders of red blood cells. 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