{"id":3508,"date":"2013-09-06T13:29:32","date_gmt":"2013-09-06T13:29:32","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3508"},"modified":"2013-09-10T07:48:06","modified_gmt":"2013-09-10T07:48:06","slug":"lysosomal-cysteine-proteinases-their-endogenous-inhibitors-and-cancer","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/lysosomal-cysteine-proteinases-their-endogenous-inhibitors-and-cancer\/","title":{"rendered":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer"},"content":{"rendered":"<p>Lysosomal cysteine proteinases, termed also cysteine cathepsins, are ubiquitous proteoly\u00adtic enzymes. The most important group of their endogenous inhibitors belongs to the cystatin superfamily, which consists of three families: ste- fins, cystatins and kininogens. The involvement of cysteine cathepsins and cystatins in proteolytic processes, leading to invasion and dissemination of tumor cells, has been confirmed by the results of several in vitro and in vivo studies. These fin\u00addings suggest that they play a role in the prognosis of the course of the disease and survival of can\u00adcer patients. The paper describes the biochemical properties of lysosomal cysteine proteinases and their endogenous inhibitors, as well as the role they play in the cell and in malignant tumor growth and dissemination. Cinical studies evaluating these new biological prognostic factors in cancer patients are reviewed. The results are encouraging, par\u00adticularly for patients with breast cancer, but they are not yet conclusive enough to be applied in the daily clinical practice along with the already estab\u00adlished prognostic factors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lysosomal cysteine proteinases, termed also cysteine cathepsins, are ubiquitous proteoly\u00adtic enzymes. The most important group of their endogenous inhibitors belongs to the cystatin superfamily, which consists of three families: ste- fins, cystatins and kininogens. The involvement of cysteine cathepsins and cystatins in proteolytic processes, leading to invasion and dissemination of tumor cells, has been confirmed [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[338,436],"tags":[],"class_list":["post-3508","post","type-post","status-publish","format-standard","hentry","category-4-1999-archive","category-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Lysosomal cysteine proteinases, termed also cysteine cathepsins, are ubiquitous proteoly\u00adtic enzymes. The most important group of their endogenous inhibitors belongs to the cystatin superfamily, which consists of three families: ste- fins, cystatins and kininogens. The involvement of cysteine cathepsins and cystatins in proteolytic processes, leading to invasion and dissemination of tumor cells, has been confirmed [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-06T13:29:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-09-10T07:48:06+00:00\" \/>\n<meta name=\"author\" content=\"Urban Neudauer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Neudauer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/\"},\"author\":{\"name\":\"Urban Neudauer\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/39b1336c1302c42805280dd6a1e7069c\"},\"headline\":\"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer\",\"datePublished\":\"2013-09-06T13:29:32+00:00\",\"dateModified\":\"2013-09-10T07:48:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/\"},\"wordCount\":177,\"commentCount\":0,\"articleSection\":[\"4\",\"Oncology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/\",\"name\":\"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2013-09-06T13:29:32+00:00\",\"dateModified\":\"2013-09-10T07:48:06+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/39b1336c1302c42805280dd6a1e7069c\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/39b1336c1302c42805280dd6a1e7069c\",\"name\":\"Urban Neudauer\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g\",\"caption\":\"Urban Neudauer\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/urban-neudauer\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/","og_locale":"en_US","og_type":"article","og_title":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi","og_description":"Lysosomal cysteine proteinases, termed also cysteine cathepsins, are ubiquitous proteoly\u00adtic enzymes. The most important group of their endogenous inhibitors belongs to the cystatin superfamily, which consists of three families: ste- fins, cystatins and kininogens. The involvement of cysteine cathepsins and cystatins in proteolytic processes, leading to invasion and dissemination of tumor cells, has been confirmed [&hellip;]","og_url":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/","og_site_name":"Dru\u0161tvo Medicinski razgledi","article_published_time":"2013-09-06T13:29:32+00:00","article_modified_time":"2013-09-10T07:48:06+00:00","author":"Urban Neudauer","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Urban Neudauer","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/#article","isPartOf":{"@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/"},"author":{"name":"Urban Neudauer","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/39b1336c1302c42805280dd6a1e7069c"},"headline":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer","datePublished":"2013-09-06T13:29:32+00:00","dateModified":"2013-09-10T07:48:06+00:00","mainEntityOfPage":{"@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/"},"wordCount":177,"commentCount":0,"articleSection":["4","Oncology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/","url":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/","name":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer - Dru\u0161tvo Medicinski razgledi","isPartOf":{"@id":"https:\/\/medrazgl.si\/#website"},"datePublished":"2013-09-06T13:29:32+00:00","dateModified":"2013-09-10T07:48:06+00:00","author":{"@id":"https:\/\/medrazgl.si\/#\/schema\/person\/39b1336c1302c42805280dd6a1e7069c"},"breadcrumb":{"@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medrazgl.si\/lizosomske-cisteinske-proteinaze-njihovi-endogeni-zaviralci-in-rak\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medrazgl.si\/en\/"},{"@type":"ListItem","position":2,"name":"Lysosomal Cysteine Proteinases, Their Endogenous inhibitors and Cancer"}]},{"@type":"WebSite","@id":"https:\/\/medrazgl.si\/#website","url":"https:\/\/medrazgl.si\/","name":"Dru\u0161tvo Medicinski razgledi","description":"Dru\u0161tvo Medicinski razgledi","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medrazgl.si\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/39b1336c1302c42805280dd6a1e7069c","name":"Urban Neudauer","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/9dcee367d5b99deae63e16a3c461f1a7dae2d29d171f2dbc5f3de73145bb4f36?s=96&d=mm&r=g","caption":"Urban Neudauer"},"url":"https:\/\/medrazgl.si\/en\/author\/urban-neudauer\/"}]}},"_links":{"self":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/3508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/comments?post=3508"}],"version-history":[{"count":0,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/3508\/revisions"}],"wp:attachment":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/media?parent=3508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/categories?post=3508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/tags?post=3508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}