{"id":3528,"date":"2013-09-06T14:08:47","date_gmt":"2013-09-06T14:08:47","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3528"},"modified":"2013-09-10T07:51:03","modified_gmt":"2013-09-10T07:51:03","slug":"erythrocyte-shape-and-deformability-due-to-variations-in-external-factors","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/erythrocyte-shape-and-deformability-due-to-variations-in-external-factors\/","title":{"rendered":"Erythrocyte shape and deformability due to variations in external factors"},"content":{"rendered":"<p>Changes in erythrocyte shape are necessary in the circulation of blood, therefore deforma\u00adbility is one of the basic properties of erythrocytes. A research project was conducted in order to determine the role of the submembrane protein skeleton in the mechanical stability of erythrocytes. Our hypothesis suggested that changes in the mechanical properties of the pro\u00adtein skeleton should result in changed deformability of the erythrocyte membrane. The pro\u00adperties affecting the deformability of erythrocytes were determined by observing changes in erythrocyte shape resulting from variations in external factors. Changes in erythrocyte shape were induced using sodium salicylate, which transforms biconcave discs (the physio\u00adlogical shape of the erythrocytes) into echinocytes, i. e. spheres with numerous membrane spicules. Diamide was added to strengthen the submembraneous protein skeleton and sha\u00adpe changes resulting from the addition of sodium salicylate were observed again. The results suggest that diamide lowers the deformability of the erythrocyte membrane. The degree of decrease in deformability depends on diamide concentration. Membrane deformability depends on the mechanical characteristics of the submembrane protein skeleton. Lower deformabi- lity is the result of higher skeleton strength.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Changes in erythrocyte shape are necessary in the circulation of blood, therefore deforma\u00adbility is one of the basic properties of erythrocytes. A research project was conducted in order to determine the role of the submembrane protein skeleton in the mechanical stability of erythrocytes. Our hypothesis suggested that changes in the mechanical properties of the pro\u00adtein [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[340,427],"tags":[],"class_list":["post-3528","post","type-post","status-publish","format-standard","hentry","category-1-2000-archive","category-surgery"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Erythrocyte shape and deformability due to variations in external factors - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/oblika-eritrocita-in-njegova-deformabilnost-pri-spremenjenih-zunanjih-pogojih\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Erythrocyte shape and deformability due to variations in external factors - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Changes in erythrocyte shape are necessary in the circulation of blood, therefore deforma\u00adbility is one of the basic properties of erythrocytes. A research project was conducted in order to determine the role of the submembrane protein skeleton in the mechanical stability of erythrocytes. 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