{"id":3721,"date":"2013-09-07T08:29:12","date_gmt":"2013-09-07T08:29:12","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3721"},"modified":"2013-09-07T09:31:13","modified_gmt":"2013-09-07T09:31:13","slug":"incidence-of-activated-protein-c-resistance-among-patients-with-deep-vein-thrombosis","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/incidence-of-activated-protein-c-resistance-among-patients-with-deep-vein-thrombosis\/","title":{"rendered":"Incidence of activated protein C resistance among patients with deep vein thrombosis"},"content":{"rendered":"<p>A group of 100 consecutive patients treated for deep vein thrombosis in the Trnovo Hospital of Internal Medicine from January 1992 to December 1994, was studied for the presence of a new type of thrombophilia\u00a0\u2013 resistance to activated protein C. There were 40 women and 60 men, aged 16 to 60 years (<img decoding=\"async\" alt=\"\\bar{x}\" src=\"http:\/\/upload.wikimedia.org\/math\/8\/4\/7\/84790e2b15a305120bc3fbeb4a4eeb4f.png\" \/> = 39). Primary deep vein thrombosis was established in 38 patients (18% women, 82% men), and sec\u00adondary deep vein thrombosis in 62 patients (53% women, 74% men). Thirty-two per cent of patients had a positive family history; 79 per cent were treated for the first episode of deep vein thrombosis and the remainder for recurrent episodes. Resistance to activated protein C was determinated using a ratio between acti\u00advated partial thromboplastin time with purified activated protein C and activated partial throm\u00adboplastin time without activated protein C. The lower normal limit was determined by measur\u00ading the activated protein C ratio in 100 sex and age matched healthy subjects (<img decoding=\"async\" alt=\"\\bar{x}\" src=\"http:\/\/upload.wikimedia.org\/math\/8\/4\/7\/84790e2b15a305120bc3fbeb4a4eeb4f.png\" \/>\u00a0\u00b1 2 SD). Subjects with an activated protein C ratio less than 2,0 were considered resistant to activated protein C. Twenty patients were exclud\u00aded from the study because of anticoagulant treatment, and 9 because of the presence of lupus anticoagulants. Activated protein C resis\u00adtance was established in 10 (14%) of the remain\u00ading 71 patients (6 women and 4 men). In the con\u00adtrol group, the prevalence of activated protein C resistance was 3 per cent (3 men) (p &lt; 0,05). One patient showed antithrombin III deficiency, and 2 patients protein C deficiency, but none of them had activated protein C resistance. There were no association between activated protein C resistance and primary or secondary deep vein thrombosis, positive family history and first or recurrent episodes of the disease. The results of the study indicate that activated protein C resistance is a frequent independent risk factor for deep vein thrombosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group of 100 consecutive patients treated for deep vein thrombosis in the Trnovo Hospital of Internal Medicine from January 1992 to December 1994, was studied for the presence of a new type of thrombophilia\u00a0\u2013 resistance to activated protein C. There were 40 women and 60 men, aged 16 to 60 years ( = 39). [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[327,407,426],"tags":[],"class_list":["post-3721","post","type-post","status-publish","format-standard","hentry","category-3-1997-archive","category-clinical-research-paper","category-internal-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Incidence of activated protein C resistance among patients with deep vein thrombosis - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/pogostost-neodzivnosti-na-aktivirani-protein-c-pri-bolnikih-z-vensko-trombozo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Incidence of activated protein C resistance among patients with deep vein thrombosis - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"A group of 100 consecutive patients treated for deep vein thrombosis in the Trnovo Hospital of Internal Medicine from January 1992 to December 1994, was studied for the presence of a new type of thrombophilia\u00a0\u2013 resistance to activated protein C. 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