{"id":3922,"date":"2013-09-07T13:58:43","date_gmt":"2013-09-07T13:58:43","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3922"},"modified":"2013-09-07T13:58:43","modified_gmt":"2013-09-07T13:58:43","slug":"the-influence-of-alpha-and-beta-fibrinogen-genes-polymorphisms-on-plasma-fibrinogen-level","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/the-influence-of-alpha-and-beta-fibrinogen-genes-polymorphisms-on-plasma-fibrinogen-level\/","title":{"rendered":"The influence of alpha and beta fibrinogen genes&#8217; polymorphisms on plasma fibrinogen level"},"content":{"rendered":"<p>Elevated plasma fibrinogen concen\u00adtration is a risk factor for cardiovascular diseases. In addition to several factors such as advanced age, diabetes mellitus, cardiovascular disea\u00adses, elevated plasma cholesterol and glucose, and smoking, also genetic factors have been shown to influence plasma fibrinogen level. Stu\u00addies on influence of <em>Taq<\/em>I, <em>Hae<\/em>III and <em>Bcl<\/em>I poly\u00admorphisms on plasma fibrinogen concentration have shown contradictory results. Therefore, the influence of <em>Taq<\/em>I, <em>Hae<\/em>III and <em>Bcl<\/em>I polymorp\u00adhisms on plasma fibrinogen concentration was in\u00advestigated in healthy subjects from Slovenia. 143 healthy volunteers were included in the cross-sectional study. Fibrinogen values were determined with a clotting assay. Polymorphisms were detected by polymerase chain reaction and digestion with <em>Taq<\/em>l, <em>Hae<\/em>III and <em>Bcl<\/em>I restriction enzymes. Statistical analysis was performed with Student&#8217;s t-test, analysis of variance,\u00a0\u03c7\u00b2 test and multiple regression analysis. ln all indi\u00adviduals mean plasma fibrinogen concentration was 2.78 g\/l (95% confidence interval 2.65\u20132.92 g\/l), in smokers higher than in non-smo\u00adkers (not significant; p = 0.40). Polymorphism <em>Taq<\/em>I was not associated with plasma fibrinogen level. There was a significant association between plasma fibrinogen concentration and <em>Hae<\/em>III (p = 0.04) and <em>Bcl<\/em>I (p = 0.04) polymorphisms in the group of non-smokers. 5% of the plasma fibrino\u00adgen variance in non-smokers could be attributed to the <em>Hae<\/em>III polymorphism (p = 0.03). ln smokers, there was no association between <em>Hae<\/em>III and <em>Bcl<\/em>I polymorphisms and plasma fibrinogen level.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elevated plasma fibrinogen concen\u00adtration is a risk factor for cardiovascular diseases. In addition to several factors such as advanced age, diabetes mellitus, cardiovascular disea\u00adses, elevated plasma cholesterol and glucose, and smoking, also genetic factors have been shown to influence plasma fibrinogen level. Stu\u00addies on influence of TaqI, HaeIII and BclI poly\u00admorphisms on plasma fibrinogen concentration [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[331,424,408],"tags":[],"class_list":["post-3922","post","type-post","status-publish","format-standard","hentry","category-2-1998-archive","category-human-genetics","category-preclinical-research-paper"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The influence of alpha and beta fibrinogen genes&#039; polymorphisms on plasma fibrinogen level - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/vpliv-polimorfizmov-v-genih-za-alfa-in-beta-fibrinogen-na-raven-fibrinogena-v-plazmi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The influence of alpha and beta fibrinogen genes&#039; polymorphisms on plasma fibrinogen level - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Elevated plasma fibrinogen concen\u00adtration is a risk factor for cardiovascular diseases. In addition to several factors such as advanced age, diabetes mellitus, cardiovascular disea\u00adses, elevated plasma cholesterol and glucose, and smoking, also genetic factors have been shown to influence plasma fibrinogen level. Stu\u00addies on influence of TaqI, HaeIII and BclI poly\u00admorphisms on plasma fibrinogen concentration [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/vpliv-polimorfizmov-v-genih-za-alfa-in-beta-fibrinogen-na-raven-fibrinogena-v-plazmi\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-07T13:58:43+00:00\" \/>\n<meta name=\"author\" content=\"Andra\u017e Nendl\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andra\u017e Nendl\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-polimorfizmov-v-genih-za-alfa-in-beta-fibrinogen-na-raven-fibrinogena-v-plazmi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/vpliv-polimorfizmov-v-genih-za-alfa-in-beta-fibrinogen-na-raven-fibrinogena-v-plazmi\\\/\"},\"author\":{\"name\":\"Andra\u017e Nendl\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/0e6cbf535aef1eb72431e6561d089434\"},\"headline\":\"The influence of alpha and beta fibrinogen genes&#8217; 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