{"id":3928,"date":"2013-09-07T14:05:19","date_gmt":"2013-09-07T14:05:19","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=3928"},"modified":"2013-09-07T14:05:19","modified_gmt":"2013-09-07T14:05:19","slug":"induction-of-collateral-sprouting-of-sensory-axons-in-the-rat","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/induction-of-collateral-sprouting-of-sensory-axons-in-the-rat\/","title":{"rendered":"Induction of collateral sprouting of sensory axons in the rat"},"content":{"rendered":"<div>\n<p>Collateral sprouting of axons in the pe\u00adripheral nervous system is a branching out\u00adgrowth of new axon terminals from non-injured axons into adjacent denervated regions of tar\u00adget tissue. The initiation of collateral sprouting is probably triggered by the interaction between the factors released by degenerated neural pathways or denervated target tissue, and pu\u00adtative interaction between the injured and non\u00adinjured neurons within a dorsal root ganglion (transneuronal mechanism). Sprouting of axons along the neurilemmal tubes of Schwann cells was investigated by an end-to-side anastomo\u00adsis of a peroneal nerve segment to the intact su\u00adral nerve on the hind limb of the rat. In group A, the peroneal nerve segment from the contrala\u00adteral limb was attached to the sural nerve. No\u00adne of the nerves on the side of the anastomosis were injured. In group B, the same procedure was used as in group A. In addition, dorso-cutaneous nerves from the L4\u2013L6 spinal segments were cut. Injured neurons were therefore present in the dorsal root ganglia from which axons of the sural nerve arise. The skin of the limb was not denervated. In group C, an end-to-side ana\u00adstomosis of the peroneal nerve segment from the ipsilateral limb was made on the sural ner\u00adve. On the same limb, the saphenus nerve was cut and ligated. The skin around the terminal in\u00adnervation field of the sural nerve was therefore denervated. The growth of sensory axon sprouts into the anastomosed nerve segments was mo\u00adnitored by the nerve-pinch test. In addition, the number of myelinated axons in the anastomosed nerve cross-sections was counted. Eight weeks after surgery the nerve-pinch test showed no sprouting of the sural nerve into the anasto\u00admosed nerve segments of the peroneal nerve in any animal in group A. In contrast, we detected sprouting in all group C animals and in four out of five animals in group B. We found only few myelinated fibres in the anastomosed peroneal nerves in group A. This was statistically signifi\u00adcantly less than in groups B and C (p &lt; 0.05). Mye\u00adlinated fibres in the anastomosed peroneal nerve in group B significantly outnumbered those in group C (p &lt; 0.02). We found out that collateral sprouting cannot be induced by Schwann cell tu\u00adbes alone, but rather denervated target tissue or transneuronal mechanisms are needed to induce the process. Transneuronal mechanism is an im\u00adportant factor stimulating the initiation of colla\u00adteral sprouting.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Collateral sprouting of axons in the pe\u00adripheral nervous system is a branching out\u00adgrowth of new axon terminals from non-injured axons into adjacent denervated regions of tar\u00adget tissue. The initiation of collateral sprouting is probably triggered by the interaction between the factors released by degenerated neural pathways or denervated target tissue, and pu\u00adtative interaction between the [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[331,433,439,408],"tags":[],"class_list":["post-3928","post","type-post","status-publish","format-standard","hentry","category-2-1998-archive","category-neurology","category-pathophysiology","category-preclinical-research-paper"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Induction of collateral sprouting of sensory axons in the rat - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Induction of collateral sprouting of sensory axons in the rat - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Collateral sprouting of axons in the pe\u00adripheral nervous system is a branching out\u00adgrowth of new axon terminals from non-injured axons into adjacent denervated regions of tar\u00adget tissue. The initiation of collateral sprouting is probably triggered by the interaction between the factors released by degenerated neural pathways or denervated target tissue, and pu\u00adtative interaction between the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-07T14:05:19+00:00\" \/>\n<meta name=\"author\" content=\"Andra\u017e Nendl\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andra\u017e Nendl\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/\"},\"author\":{\"name\":\"Andra\u017e Nendl\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/0e6cbf535aef1eb72431e6561d089434\"},\"headline\":\"Induction of collateral sprouting of sensory axons in the rat\",\"datePublished\":\"2013-09-07T14:05:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/\"},\"wordCount\":418,\"commentCount\":0,\"articleSection\":[\"2\",\"Neurology\",\"Pathophysiology\",\"Preclinical research paper\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/sprozenje-kolateralnega-brstenja-senzoricnih-aksonov-pri-podgani\\\/\",\"name\":\"Induction of collateral sprouting of sensory axons in the rat - 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