Antidepressants are known to influence the kinetics of histamine. The purpose of this study was twofold: to determine the influence of various doses of antidepressants fluvoxamine and mapro\u00adtiline on induced histamine liberation and its further elimination and to find out whether histamine elim\u00adination is influenced by its redistribution from plas\u00adma to blood. Rats (n = 24) were pre-treated with two doses of antidepressant at an interval of 24 hours. One hour after the administration of the second dose of antidepressants, the rats received histamine liber\u00adator\u00a0\u2013 compound 48\/80 (0.05 pg\/g) or exogenous histmine (10 pg\/g). Blood samples were taken from the carotid artery at 5 and 15 minutes after the injec\u00adtion of the histamine liberator\u00a0\u2013 for measurements of plasma histamine levels, and at 2 minutes after the injection of exogenous histamine\u00a0\u2013 for separate determinations of plasma and blood histamine lev\u00adels. After a two-step purification procedure, hista\u00admine levels were measured by spectrofluorometry. Both antidepressants inhibited the rise of plasma histamine because of the effects of compound 48\/80. The study animals showed significantly higher val\u00adues of elimination constants than controls. It is as\u00adsumed that antidepressants inhibit histamine libera\u00adtion and promote its elimination. Rats pre-treated with antidepressants had lower plasma and blood hist\u00adamine levels after exogenous histamine injection than control animals, while their plasma histamine\/blood histamine ratio did not change significantly. We suppose that accelerated elimination of hista\u00admine is not the result of its redistribution from plas\u00adma to blood and blood elements but is rather the consequence of increased metabolism of histamine and\/or its binding in other tissues.<\/p>\n","protected":false},"excerpt":{"rendered":"
Antidepressants are known to influence the kinetics of histamine. The purpose of this study was twofold: to determine the influence of various doses of antidepressants fluvoxamine and mapro\u00adtiline on induced histamine liberation and its further elimination and to find out whether histamine elim\u00adination is influenced by its redistribution from plas\u00adma to blood. Rats (n = […]<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[332,439,418,408],"tags":[],"class_list":["post-3992","post","type-post","status-publish","format-standard","hentry","category-3-1998-archive","category-pathophysiology","category-pharmacology-and-experimental-toxicology","category-preclinical-research-paper"],"acf":[],"yoast_head":"\n