{"id":4039,"date":"2013-09-08T08:21:10","date_gmt":"2013-09-08T08:21:10","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=4039"},"modified":"2013-09-08T08:21:10","modified_gmt":"2013-09-08T08:21:10","slug":"expression-of-cyclooxygenase-1-and-cyclooxygenase-2-enzymes-in-normal-heart-and-in-myocardial-infarction","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/expression-of-cyclooxygenase-1-and-cyclooxygenase-2-enzymes-in-normal-heart-and-in-myocardial-infarction\/","title":{"rendered":"Expression of Cyclooxygenase-1 and Cyclooxygenase-2 Enzymes in Normal Heart and in Myocardial Infarction"},"content":{"rendered":"<div>\n<p>Cyclooxygenase (COX) is a key enzyme in prostanoid synthesis which plays an important role in many cell functions. COX exists in two isoforms: COX-1 and COX-2. Our aim was to analyse the expression of both COX isoforms in the normal human heart and in myocardial infarc\u00adtion, with a hypothesis that COX-1 is expressed mostly or exclusively in the normal heart and COX-2 in myocardial infarction. Our study included autopsy samples of heart tissue divid\u00aded into 2 groups: one consisted of heart tissue samples from 10 healthy persons who died in car accidents, and the other of heart tissue samples from 35 patients with myocardial infarc\u00adtion. Tissue samples were stained with hematoxylline and eosin and immunohistochemistry was used for detection of COX-1 and COX-2. In the normal heart, COX-1 is expressed in blood vessels and endocardium, but not in cardiomyocytes. COX-2 is not expressed in the normal heart or very rarely in occasional myocytes. In contrast, COX-2, but not COX-1 is induced in cardiomyocytes in myocardial infarction. Both isoforms are present in components of gran\u00adulation tissue and fibrous tissue. COX-1-positivity was intense and almost diffuse, while COX-2 positivity was focal. Our results indicate that COX-1 maintains normal homeostasis in the heart and that inflammatory reaction in myocardial infarction is probably mediated by COX-2. It appears that both COX-1 and COX-2 contribute to the healing processes and scar formation after myocardial infarction.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cyclooxygenase (COX) is a key enzyme in prostanoid synthesis which plays an important role in many cell functions. COX exists in two isoforms: COX-1 and COX-2. Our aim was to analyse the expression of both COX isoforms in the normal human heart and in myocardial infarc\u00adtion, with a hypothesis that COX-1 is expressed mostly or [&hellip;]<\/p>\n","protected":false},"author":28,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[],"tags":[],"class_list":["post-4039","post","type-post","status-publish","format-standard","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Expression of Cyclooxygenase-1 and Cyclooxygenase-2 Enzymes in Normal Heart and in Myocardial Infarction - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Expression of Cyclooxygenase-1 and Cyclooxygenase-2 Enzymes in Normal Heart and in Myocardial Infarction - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Cyclooxygenase (COX) is a key enzyme in prostanoid synthesis which plays an important role in many cell functions. COX exists in two isoforms: COX-1 and COX-2. Our aim was to analyse the expression of both COX isoforms in the normal human heart and in myocardial infarc\u00adtion, with a hypothesis that COX-1 is expressed mostly or [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-08T08:21:10+00:00\" \/>\n<meta name=\"author\" content=\"Sara Mugerli\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sara Mugerli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/\"},\"author\":{\"name\":\"Sara Mugerli\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/16ac1255597e2446044919a9c6902c99\"},\"headline\":\"Expression of Cyclooxygenase-1 and Cyclooxygenase-2 Enzymes in Normal Heart and in Myocardial Infarction\",\"datePublished\":\"2013-09-08T08:21:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/\"},\"wordCount\":245,\"commentCount\":0,\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/izrazanje-encimov-ciklooksgenaza-1-in-ciklooksigenaza-2-v-zdravem-srcu-in-v-srcnem-infarktu-pri-cloveku\\\/\",\"name\":\"Expression of Cyclooxygenase-1 and Cyclooxygenase-2 Enzymes in Normal Heart and in Myocardial Infarction - 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