{"id":4156,"date":"2013-09-08T12:30:28","date_gmt":"2013-09-08T12:30:28","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=4156"},"modified":"2013-09-10T07:54:06","modified_gmt":"2013-09-10T07:54:06","slug":"molecular-genetics-in-diagnosis-of-hereditary-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/molecular-genetics-in-diagnosis-of-hereditary-colorectal-cancer\/","title":{"rendered":"Molecular Genetics in Diagnosis of Hereditary Colorectal Cancer"},"content":{"rendered":"<div>\n<p align=\"left\">A family with autosomal dominant cancer was first reported one century ago. The heredi\u00adtary nature of some forms of colorectal cancer was confirmed less than 10 years ago by the detection of mutations associated with genetic predispositions to mendelian colorectal can\u00adcer. The paper presents several hereditary types of colorectal carcinoma, as well as their phe\u00adnotypic and genetic characteristics, which allow for differential diagnosis of various syndromes. The role of molecular genetic technology in familial and population genetics is stressed. The paper describes the molecular genetic technique used at the Laboratory of mole\u00adcular genetics Institute of Pathology Medical Faculty Ljubljana for the identification of fami\u00adlies with hereditary non-polyposis colorectal cancer in the Slovene population.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A family with autosomal dominant cancer was first reported one century ago. The heredi\u00adtary nature of some forms of colorectal cancer was confirmed less than 10 years ago by the detection of mutations associated with genetic predispositions to mendelian colorectal can\u00adcer. The paper presents several hereditary types of colorectal carcinoma, as well as their phe\u00adnotypic [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[340,412,436],"tags":[],"class_list":["post-4156","post","type-post","status-publish","format-standard","hentry","category-1-2000-archive","category-biochemistry","category-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Molecular Genetics in Diagnosis of Hereditary Colorectal Cancer - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Genetics in Diagnosis of Hereditary Colorectal Cancer - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"A family with autosomal dominant cancer was first reported one century ago. The heredi\u00adtary nature of some forms of colorectal cancer was confirmed less than 10 years ago by the detection of mutations associated with genetic predispositions to mendelian colorectal can\u00adcer. The paper presents several hereditary types of colorectal carcinoma, as well as their phe\u00adnotypic [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2013-09-08T12:30:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-09-10T07:54:06+00:00\" \/>\n<meta name=\"author\" content=\"Urban Neudauer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Neudauer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/\"},\"author\":{\"name\":\"Urban Neudauer\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/39b1336c1302c42805280dd6a1e7069c\"},\"headline\":\"Molecular Genetics in Diagnosis of Hereditary Colorectal Cancer\",\"datePublished\":\"2013-09-08T12:30:28+00:00\",\"dateModified\":\"2013-09-10T07:54:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/\"},\"wordCount\":125,\"commentCount\":0,\"articleSection\":[\"1\",\"Biochemistry\",\"Oncology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/molekularna-genetika-v-diagnostiki-dednega-raka-sirokega-crevesa-in-danke\\\/\",\"name\":\"Molecular Genetics in Diagnosis of Hereditary Colorectal Cancer - 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