{"id":4248,"date":"2013-09-08T14:16:40","date_gmt":"2013-09-08T14:16:40","guid":{"rendered":"http:\/\/test-medrazgl.aed-baza.si\/?p=4248"},"modified":"2013-09-08T14:36:50","modified_gmt":"2013-09-08T14:36:50","slug":"structure-activity-relationships-of-some-peptide-antibiotics","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/structure-activity-relationships-of-some-peptide-antibiotics\/","title":{"rendered":"Structure-activity Relationships of Some Peptide Antibiotics"},"content":{"rendered":"<div>\n<p>Peptide antibiotics are a very heterogenic group of antibiotics. Among them we differ cyclic, linear, non-substituted or substituted peptide antibiotics. The main feature of almost all pep\u00adtide antibiotics is their amphiphilicity. Primary structure of linear peptide antibiotics is defined as the covalent backbone structure of polypeptide chains, including the sequence of amino acid residues. The predominant structure of long length antibiotic peptides in an aqueous medium is the helical structure called alpha helix. Short length monomer peptides have very little secondary structure and exist mainly as a random coil. A typical amphipathic alpha he\u00adlix is characterized by a flat hydrophobic and hydrophilic face along the axe of the molecule that interacts with polar and non-polar surfaces, like phospholipid bilayers, by packing around them in rigid, well-ordered, alpha helical arrangements. Cyclic peptide antibiotics show litt\u00adle potency for alpha helical conformation since they adopt bulky non-peptide groups. Rather, they express polar and non-polar regions that alternate with each other, form \u2018leafs\u2019 that re\u00adsemble on beta sheets. Knowledge about structural characteristics of peptide antibiotics is very important for the development of new class of highly efficient antibiotic drugs.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Peptide antibiotics are a very heterogenic group of antibiotics. Among them we differ cyclic, linear, non-substituted or substituted peptide antibiotics. The main feature of almost all pep\u00adtide antibiotics is their amphiphilicity. Primary structure of linear peptide antibiotics is defined as the covalent backbone structure of polypeptide chains, including the sequence of amino acid residues. The [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[284],"tags":[],"class_list":["post-4248","post","type-post","status-publish","format-standard","hentry","category-latest"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Structure-activity Relationships of Some Peptide Antibiotics - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/strukturne-znacilnosti-in-delovanje-nekaterih-peptidnih-antibiotikov\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Structure-activity Relationships of Some Peptide Antibiotics - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Peptide antibiotics are a very heterogenic group of antibiotics. Among them we differ cyclic, linear, non-substituted or substituted peptide antibiotics. The main feature of almost all pep\u00adtide antibiotics is their amphiphilicity. Primary structure of linear peptide antibiotics is defined as the covalent backbone structure of polypeptide chains, including the sequence of amino acid residues. 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