{"id":6963,"date":"2014-03-02T13:40:49","date_gmt":"2014-03-02T12:40:49","guid":{"rendered":"http:\/\/medrazgl.si\/?p=6963"},"modified":"2014-03-02T13:40:49","modified_gmt":"2014-03-02T12:40:49","slug":"the-influence-of-amitriptyline-and-sertraline-in-vitro-on-the-kinetics-of-exogenous-histamine-in-cat-blood","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/the-influence-of-amitriptyline-and-sertraline-in-vitro-on-the-kinetics-of-exogenous-histamine-in-cat-blood\/","title":{"rendered":"The Influence of Amitriptyline and Sertraline in Vitro on the Kinetics of Exogenous Histamine in Cat Blood"},"content":{"rendered":"<p>Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants modify the pharmacokinetics of exogenous histamine in cats and rats. They decrease elevated histamine concentrations in plasma after an injection of exogenous histamine. Consequently, animals which have not been treated with antidepres\u00adsants have significantly elevated histamine concentrations after an intravenous injection of this amine. In order to determine the extent to which blood cells participate in the modifi\u00adcation of exogenous histamine kinetics, in vitro tests were performed on cat blood. After taking blood samples, the plasma was separated from blood cells and exogenous histamine and two antidepressants, amitriptyline and sertraline, were added to the blood cells in vitro. The con\u00adcentration of histamine in the samples was determined spectroflourometrically, while methylhistamine was determined using HPLC. The results indicate that both amitriptyline and sertraline in vitro increase the reuptake of exogenous histamine in cat blood cells, although the effect of sertraline is more significant than that of amitriptyline.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants modify the pharmacokinetics of exogenous histamine in cats and rats. They decrease elevated histamine concentrations in plasma after an injection of exogenous histamine. Consequently, animals [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[362,418,408],"tags":[],"class_list":["post-6963","post","type-post","status-publish","format-standard","hentry","category-4-2004-archive","category-pharmacology-and-experimental-toxicology","category-preclinical-research-paper"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Influence of Amitriptyline and Sertraline in Vitro on the Kinetics of Exogenous Histamine in Cat Blood - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/vpliv-amitriptilina-in-sertralina-na-kinetiko-eksogenega-histamina-v-krvi-macke-v-in-vitro-poskusih\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Influence of Amitriptyline and Sertraline in Vitro on the Kinetics of Exogenous Histamine in Cat Blood - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants modify the pharmacokinetics of exogenous histamine in cats and rats. They decrease elevated histamine concentrations in plasma after an injection of exogenous histamine. 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