{"id":7600,"date":"2014-06-01T17:20:01","date_gmt":"2014-06-01T15:20:01","guid":{"rendered":"http:\/\/medrazgl.si\/?p=7600"},"modified":"2014-06-03T01:49:57","modified_gmt":"2014-06-02T23:49:57","slug":"amphetamine-and-methamphetamine-mechanism-of-action-effects-poisoning-and-diagnostics","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/amphetamine-and-methamphetamine-mechanism-of-action-effects-poisoning-and-diagnostics\/","title":{"rendered":"Amphetamine and Methamphetamine: Mechanism of Action, Effects, Poisoning and Diagnostics"},"content":{"rendered":"<p>Amphetamine consumption is highly spread throughout the world, especially in the Unites\u00a0States of America, Australia and Asia. In Slovenia, the consumption of amphetamines and\u00a0methamphetamines is not so spread and, further more, it is also not increasing. Amphetamines cause a euphoric state. Their effects are an immediate consequence of an increased\u00a0release of dopamine, serotonin and noradrenaline in synapses of the central nervous system.\u00a0Amphetamines are classified as substances that share an amphetamine skeleton. Amphetamines differ in their pharmacokinetic properties (absorption, distribution, metabolism and\u00a0excretion)\u00a0and potency, and some amphetamines also have a specific mechanism of action.\u00a0Amphetamine usage is dangerous as can result in potentially lethal acute poisoning because\u00a0of sympathomimetic overstimulation of the cardio vascular system. The first choice for the treatment of poisoning would be benzodiazepines, which suppress the nervous system. A prolonged,\u00a0chronic usage of amphetamines, particularly methamphetamine, is neurotoxic and\u00a0produces distinctive neurocognitive disorders. Despite being dangerous, amphetamines are\u00a0used to treat attention deficit hyperactivity disorder and narcolepsy. This type of treatment\u00a0is not registered in the European Union, however, because of its potential for the development of addiction. Unfortunately, there is no effective pharmacotherapy for the treatment\u00a0of amphetamine addiction, but studies about the usage of the atypical antipsychotic and calcium channel blocker isradipine and the antiepileptic drug vigabatrin show promising results\u00a0for future treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amphetamine consumption is highly spread throughout the world, especially in the Unites\u00a0States of America, Australia and Asia. In Slovenia, the consumption of amphetamines and\u00a0methamphetamines is not so spread and, further more, it is also not increasing. Amphetamines cause a euphoric state. Their effects are an immediate consequence of an increased\u00a0release of dopamine, serotonin and noradrenaline [&hellip;]<\/p>\n","protected":false},"author":44,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[393,418,446],"tags":[],"class_list":["post-7600","post","type-post","status-publish","format-standard","hentry","category-1-2011-archive","category-pharmacology-and-experimental-toxicology","category-toxicology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amphetamine and Methamphetamine: Mechanism of Action, Effects, Poisoning and Diagnostics - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/amfetamin-in-metamfetamin-mehanizem-delovanja-ucinki-zastrupitev-in-diagnostika\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Amphetamine and Methamphetamine: Mechanism of Action, Effects, Poisoning and Diagnostics - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Amphetamine consumption is highly spread throughout the world, especially in the Unites\u00a0States of America, Australia and Asia. In Slovenia, the consumption of amphetamines and\u00a0methamphetamines is not so spread and, further more, it is also not increasing. Amphetamines cause a euphoric state. 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