{"id":7623,"date":"2014-06-01T18:49:07","date_gmt":"2014-06-01T16:49:07","guid":{"rendered":"http:\/\/medrazgl.si\/?p=7623"},"modified":"2014-06-03T02:05:41","modified_gmt":"2014-06-03T00:05:41","slug":"multiple-keratoacanthomas","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/multiple-keratoacanthomas\/","title":{"rendered":"Multiple Keratoacanthomas"},"content":{"rendered":"<p>Keratoacanthoma is an epidermal malignancy, which histopathologically resembles to squamous\u00a0cell carcinoma. Multiple keratoacanthomas are a heterogeneous group of inherited or\u00a0acquired disorders. Several different mechanisms may be responsible for their development,\u00a0including UV radiation, ionizing radiation, viruses (human papillomavirus), and chemical carcinogens (tar), as well as certain immunologic and genetic factors. The article is a report on\u00a0three patients who developed multiple keratoacanthomas and several squamous cell or basal\u00a0cell carcinomas while receiving photochemotherapy. They had a history of psoriasis of over\u00a040 years&#8217; duration and had been periodically treated with systemic photochemotherapy because of generalized psoriasis that was resistant to topical treatment. Throughout the years\u00a0of treatment with photochemotherapy, they received high cumulative doses of UVA rays. Because of development of these cutaneous tumors, photochemotherapy was discontinued, but continued\u00a0development of the above-mentioned lesions was nevertheless noticed. Due to frequent\u00a0recurrences of psoriasis, these patients receive high doses of UVA rays in their life time and therefore have a significantly increased risk for the development of nonmelanoma skin malignancies.\u00a0The occurrence of multiple keratoacanthomas in the presented cases can be attributed\u00a0with a great probability to long-term photochemotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Keratoacanthoma is an epidermal malignancy, which histopathologically resembles to squamous\u00a0cell carcinoma. Multiple keratoacanthomas are a heterogeneous group of inherited or\u00a0acquired disorders. Several different mechanisms may be responsible for their development,\u00a0including UV radiation, ionizing radiation, viruses (human papillomavirus), and chemical carcinogens (tar), as well as certain immunologic and genetic factors. The article is a report on\u00a0three [&hellip;]<\/p>\n","protected":false},"author":44,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[393,416,436],"tags":[],"class_list":["post-7623","post","type-post","status-publish","format-standard","hentry","category-1-2011-archive","category-dermatovenerology","category-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Multiple Keratoacanthomas - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/multipli-keratoakantomi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multiple Keratoacanthomas - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Keratoacanthoma is an epidermal malignancy, which histopathologically resembles to squamous\u00a0cell carcinoma. Multiple keratoacanthomas are a heterogeneous group of inherited or\u00a0acquired disorders. Several different mechanisms may be responsible for their development,\u00a0including UV radiation, ionizing radiation, viruses (human papillomavirus), and chemical carcinogens (tar), as well as certain immunologic and genetic factors. 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