BACKGROUNDS. Celiac disease is a systemic, immune-mediated disease, triggered by the ingestion of gluten-containing grains in susceptible individuals. Recently there have been changes\u00a0in diagnosis of celiac disease, mainly due to the discovery of serological tests. Epidemiological studies, done so far in northeastern Slovenia, showed that cumulative incidence was\u00a0rising and typical presentation was dominant.<\/p>\n
METHODS. The inclusion criteria were: born\u00a0in northeastern Slovenia between the years 1999 and 2009, diagnosis of celiac disease between 1999 and 2009, clinical features of celiac disease, presence of serological markers,\u00a0intestinal biopsy and typical histological appearance of the jejunal mucosa. We performed\u00a0a retrospective collection of clinical data for each patient. The cumulative incidence for each\u00a0birth cohort was calculated. Serological markers (anti-endomisium antibodies and anti-transglutaminase antibodies) were determined in all patients, as was the presence of the human\u00a0leukocyte antigen DQ2 or human leukocyte antigen DQ8. Intestinal biopsy was performed\u00a0and the degree of villous atrophy determined using descriptive classification.<\/p>\n
RESULTS. The\u00a0study included 72 patients. All of our patients fulfilled the majority of diagnostic criteria.\u00a0All our patients carried one of the human leukocyte antigen DQ risk alleles. Cumulative incidence from 1999 to 2004 is increasing and from 2004 onwards cumulative incidence stabilize. Typical clinical presentation of celiac disease is dominant.<\/p>\n
CONCLUSIONS. Cumulative\u00a0incidence of celiac disease in northeastern Slovenia has stabilized. Typical clinical presentation with chronic diarrhea, abdominal distention and failure to thrive is dominant. Results\u00a0of serologic tests showed that sensitivity of anti-endomisium antibodies serologic tests is lower\u00a0in patients that had minor lesion of intestinal mucosa at biopsy. Genetic tests showed that\u00a0most of our patients carried the human leukocyte antigen DQ2 allele.<\/p>\n","protected":false},"excerpt":{"rendered":"
BACKGROUNDS. Celiac disease is a systemic, immune-mediated disease, triggered by the ingestion of gluten-containing grains in susceptible individuals. Recently there have been changes\u00a0in diagnosis of celiac disease, mainly due to the discovery of serological tests. Epidemiological studies, done so far in northeastern Slovenia, showed that cumulative incidence was\u00a0rising and typical presentation was dominant. METHODS. The […]<\/p>\n","protected":false},"author":44,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[394,407,426],"tags":[],"class_list":["post-7642","post","type-post","status-publish","format-standard","hentry","category-2-2011-archive","category-clinical-research-paper","category-internal-medicine"],"acf":[],"yoast_head":"\n