{"id":8169,"date":"2014-06-02T22:15:49","date_gmt":"2014-06-02T20:15:49","guid":{"rendered":"http:\/\/medrazgl.si\/?p=8169"},"modified":"2014-06-03T08:25:35","modified_gmt":"2014-06-03T06:25:35","slug":"is-the-use-of-cognitive-modulators-reasonable-in-treatment-of-bipolar-mood-disorder","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/is-the-use-of-cognitive-modulators-reasonable-in-treatment-of-bipolar-mood-disorder\/","title":{"rendered":"Is the Use of Cognitive Modulators Reasonable in Treatment of Bipolar Mood Disorder?"},"content":{"rendered":"<div>\n<p align=\"left\">A significant proportion of patients with bipolar disorder do not respond satisfactorily to con\u00adventional pharmacological treatment with lithium, anticonvulsants, antipsychotics and antidepressants. Several studies point to high risk for chronic illness and relapse despite recei\u00adving available therapy. At this moment we do not even have a common definition for treat\u00adment-resistant bipolar disorder, which makes assessing the number of patients refractory to treatment very difficult. Not only resistance to treatment, but also the evidences of cogniti\u00adve decline in chronic patients speak for the need for complementary therapies. Cognitive modu\u00adlators such as donepezil, galantamine, rivastigmine and memantine are drugs that are primarily used in treating various forms of dementia. This paper collects currently available data on the use of cognitive modulators as augmentation therapy of treatment-resistant bipolar disor\u00adder and in treatment of cognitive decline in this disease. Encouraging results of studies and case reports suggest that further research into the use of cognitive modulators in bipolar mood disorder is reasonable, primarily in terms of controlled randomized double-blind studies.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A significant proportion of patients with bipolar disorder do not respond satisfactorily to con\u00adventional pharmacological treatment with lithium, anticonvulsants, antipsychotics and antidepressants. Several studies point to high risk for chronic illness and relapse despite recei\u00adving available therapy. At this moment we do not even have a common definition for treat\u00adment-resistant bipolar disorder, which makes assessing [&hellip;]<\/p>\n","protected":false},"author":44,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[395,442],"tags":[],"class_list":["post-8169","post","type-post","status-publish","format-standard","hentry","category-3-2011-archive","category-psychiatry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is the Use of Cognitive Modulators Reasonable in Treatment of Bipolar Mood Disorder? - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is the Use of Cognitive Modulators Reasonable in Treatment of Bipolar Mood Disorder? - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"A significant proportion of patients with bipolar disorder do not respond satisfactorily to con\u00adventional pharmacological treatment with lithium, anticonvulsants, antipsychotics and antidepressants. Several studies point to high risk for chronic illness and relapse despite recei\u00adving available therapy. At this moment we do not even have a common definition for treat\u00adment-resistant bipolar disorder, which makes assessing [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2014-06-02T20:15:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2014-06-03T06:25:35+00:00\" \/>\n<meta name=\"author\" content=\"Rok Ku\u010dan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rok Ku\u010dan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/\"},\"author\":{\"name\":\"Rok Ku\u010dan\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/36f386bf312b50a17856329ce3c945f0\"},\"headline\":\"Is the Use of Cognitive Modulators Reasonable in Treatment of Bipolar Mood Disorder?\",\"datePublished\":\"2014-06-02T20:15:49+00:00\",\"dateModified\":\"2014-06-03T06:25:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/\"},\"wordCount\":185,\"commentCount\":0,\"articleSection\":[\"3\",\"Psychiatry\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/ali-je-uporaba-kognitivnih-modulatorjev-smiselna-pri-zdravljenju-bipolarne-motnje-razpolozenja\\\/\",\"name\":\"Is the Use of Cognitive Modulators Reasonable in Treatment of Bipolar Mood Disorder? 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