{"id":9990,"date":"2017-11-30T12:57:55","date_gmt":"2017-11-30T11:57:55","guid":{"rendered":"http:\/\/medrazgl.si\/en\/?p=9990"},"modified":"2018-04-01T22:14:03","modified_gmt":"2018-04-01T20:14:03","slug":"cancer-stem-cells-key-to-improved-treatment-of-malignant-melanoma","status":"publish","type":"post","link":"https:\/\/medrazgl.si\/en\/cancer-stem-cells-key-to-improved-treatment-of-malignant-melanoma\/","title":{"rendered":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?"},"content":{"rendered":"<p>Malignant melanoma is an unpredictable, aggressive disease with the fastest growing incidence among all cancers. Its high metastatic potential and tendency to relapse are poorly prevented by existing systemic therapy. In spite of apparent eradication through treatment in accordance with the newest clinical guidelines, the disease is likely to recur. Cancer stem cells, with their plasticity, self-renewal ability and drug resistance represent a highly probable culprit for these relapses. This special subpopulation of cancer cells is relatively small in number, but harbors uncanny tumor initiating, invasion and metastasis potential. While their very existence remains a controversy among research groups, the evidence for their prominent role in malignancies has multiplied with the number of studies performed in this area in the past few years. Unraveling the molecular mechanisms behind these cells&#8217; unique abilities could lead to novel strategies in the diagnostics and treatment of malignant melanoma. Since the diagnostic value of genetic testing has proven questionable, certain recently discovered biomarkers offer a promising alternative. They may also serve as targets for immunotherapy and reprogramming that could lead to improving patient survival and potentially finally curing this insidious disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Malignant melanoma is an unpredictable, aggressive disease with the fastest growing incidence among all cancers. Its high metastatic potential and tendency to relapse are poorly prevented by existing systemic therapy. In spite of apparent eradication through treatment in accordance with the newest clinical guidelines, the disease is likely to recur. Cancer stem cells, with their [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[794,423,436],"tags":[],"class_list":["post-9990","post","type-post","status-publish","format-standard","hentry","category-2-2014-archive","category-histology-and-embryology","category-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"og:description\" content=\"Malignant melanoma is an unpredictable, aggressive disease with the fastest growing incidence among all cancers. Its high metastatic potential and tendency to relapse are poorly prevented by existing systemic therapy. In spite of apparent eradication through treatment in accordance with the newest clinical guidelines, the disease is likely to recur. Cancer stem cells, with their [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/\" \/>\n<meta property=\"og:site_name\" content=\"Dru\u0161tvo Medicinski razgledi\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-30T11:57:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-04-01T20:14:03+00:00\" \/>\n<meta name=\"author\" content=\"Matej Gori\u010dar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Matej Gori\u010dar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/\"},\"author\":{\"name\":\"Matej Gori\u010dar\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\"},\"headline\":\"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?\",\"datePublished\":\"2017-11-30T11:57:55+00:00\",\"dateModified\":\"2018-04-01T20:14:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/\"},\"wordCount\":197,\"commentCount\":0,\"articleSection\":[\"2\",\"Histology and Embryology\",\"Oncology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/\",\"name\":\"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\"},\"datePublished\":\"2017-11-30T11:57:55+00:00\",\"dateModified\":\"2018-04-01T20:14:03+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#website\",\"url\":\"https:\\\/\\\/medrazgl.si\\\/\",\"name\":\"Dru\u0161tvo Medicinski razgledi\",\"description\":\"Dru\u0161tvo Medicinski razgledi\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medrazgl.si\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medrazgl.si\\\/#\\\/schema\\\/person\\\/34d7ecbf2c9ebf96d826c5634daed7ca\",\"name\":\"Matej Gori\u010dar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g\",\"caption\":\"Matej Gori\u010dar\"},\"url\":\"https:\\\/\\\/medrazgl.si\\\/en\\\/author\\\/matej-goricar\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/","og_locale":"en_US","og_type":"article","og_title":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi","og_description":"Malignant melanoma is an unpredictable, aggressive disease with the fastest growing incidence among all cancers. Its high metastatic potential and tendency to relapse are poorly prevented by existing systemic therapy. In spite of apparent eradication through treatment in accordance with the newest clinical guidelines, the disease is likely to recur. Cancer stem cells, with their [&hellip;]","og_url":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/","og_site_name":"Dru\u0161tvo Medicinski razgledi","article_published_time":"2017-11-30T11:57:55+00:00","article_modified_time":"2018-04-01T20:14:03+00:00","author":"Matej Gori\u010dar","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Matej Gori\u010dar","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/#article","isPartOf":{"@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/"},"author":{"name":"Matej Gori\u010dar","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca"},"headline":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?","datePublished":"2017-11-30T11:57:55+00:00","dateModified":"2018-04-01T20:14:03+00:00","mainEntityOfPage":{"@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/"},"wordCount":197,"commentCount":0,"articleSection":["2","Histology and Embryology","Oncology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/","url":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/","name":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma? - Dru\u0161tvo Medicinski razgledi","isPartOf":{"@id":"https:\/\/medrazgl.si\/#website"},"datePublished":"2017-11-30T11:57:55+00:00","dateModified":"2018-04-01T20:14:03+00:00","author":{"@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca"},"breadcrumb":{"@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medrazgl.si\/rakaste-maticne-celice-kljuc-do-uspesnejsega-zdravljenja-malignega-melanoma\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medrazgl.si\/en\/"},{"@type":"ListItem","position":2,"name":"Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?"}]},{"@type":"WebSite","@id":"https:\/\/medrazgl.si\/#website","url":"https:\/\/medrazgl.si\/","name":"Dru\u0161tvo Medicinski razgledi","description":"Dru\u0161tvo Medicinski razgledi","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medrazgl.si\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medrazgl.si\/#\/schema\/person\/34d7ecbf2c9ebf96d826c5634daed7ca","name":"Matej Gori\u010dar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/003f8c4b027e5f6651eec48509adb56770581509ef227519d254087e28cffac3?s=96&d=mm&r=g","caption":"Matej Gori\u010dar"},"url":"https:\/\/medrazgl.si\/en\/author\/matej-goricar\/"}]}},"_links":{"self":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/9990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/comments?post=9990"}],"version-history":[{"count":0,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/posts\/9990\/revisions"}],"wp:attachment":[{"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/media?parent=9990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/categories?post=9990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medrazgl.si\/en\/wp-json\/wp\/v2\/tags?post=9990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}