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Speaking of acute hepatitis, acute viral hepatitis is what we usually have in mind, although a similar liver inflammation can also be caused by many other etiologic agents such as bacteria, protozoa, toxic substances and others. In cases of suspect acute hepatitis where cholestatic jaundice is the leading symptom, extrahepatic cholestasis must first be excluded. In the next diagnostic step we try to define the aetiology of the disease on the basis of epidemiological data, clinical picture, laboratory and serological tests. A case of acute hepatitis in a 52-year-old female with marked jaundice but otherwise poor symptoms and signs is presented. The most common causes of acute hepatitis were excluded but herpes simplex virus infection and infections with some other rare micro-organisms could not be excluded.