Hirschsprung's disease is a congenital anomaly characterized by the absence of intramural ganglion cells of the bowel. The length of the aganglionic segment varies. Aganglionosis is most frequently confined to…

Skeletal muscle is the most abundant of the human body's tissues and it represents a substantial percentage of body mass. Its main function is contraction, which produces force for different types…

Breast cancer is a serious health care problem, since it is the most common type of cancer in women and a leading cause of death from cancer. A diagnostic approach…

Abstract. Glucagonoma is a rare neuroendocrine tumor with pancreatic alpha cell differen­tiation. This tumor is characterized by hypersecretion of a peptide hormone glucagon, which can be detected in this type…

The histomorphometric analysis represents invasive diagnostic method for osteoporosis and other metabolic bone diseases. The manual, semiautomatic and automatic histomorphometric method were compared by analysing the undecalcified bone samples. Validity…

Prion diseases are rare degenerative diseases of the central nervous system in humans and some other mammals. Three different etiopatogenetical forms of these diseases are recognised in humans, being, as…

The authors transplanted Ehrlich ascites tumor (EAT) cells to 90 inbred mice of CBA strain in order to investigate the role that sex of animal and dose of tumor cells…

Esophageal carcinoma is one of those malignant tumors which have the worst prognosis and exhibit a marked geographic variation in their incidence. While the incidence of esophageal squamous cell carcinoma…

The article shows a histopathological review of inflammatory bowel disease (IBD) and the associated neoplasia. Its etiology is still not well defined and it involves genetic susceptibility, abnormalities in the…

Helicobacter pylori, a spiral shaped pathogenic bacterium, was first isolated by Barry Warren and Robin Marshall about 20 years ago, earning them a Nobel Prize in Physiology or Medicine in…

Barrett's esophagus is precancerous condition in which metaplastic change from squamous to glandular epithelium of distal tubular esophagus is encountered, as a result of chronic gas­troesophageal reflux disease. Adenocarcinoma arises…

Endometrial cancer is a hormone dependent tumour. Estrogens, endogenous as well as tho­se infiltrated artificially into the organism, play a decisive part in its origin. The disease affects especially older…

In the article recent advances in the etiology of inflammatory bowel disease, which remain unk­nown despite intensive research effort, are presented. The role of the mucosal immune sys­tem in the…

Newcastle disease virus (NDV) has been shown to have an inhibitory influence on tumor growth in various experimental conditions. We studied the effect of daily application of a wild strain…

BACKGROUND. Autoimmune lymphoproliferative syndrome (ALPS) is a primary immuno­deficiency disorder characterized by immune dysregulation. ALPS is defined as chronic, nonmalignant lymphoproliferation in patients with double-negative T cell (DNT) expansion over…

In Slovenia, the use of experimental animals in education and for experimental and other scientific purposes is regulated by the Animal Protection Act and other subsidiary legal acts, in which…

The majority of primary glomerulonephritides is mediated by the deposition of circulating or in situ formed immune complexes, which may be confirmed by immunofluorescence find­ing of glomerular granular immune deposits.…

Reliable diagnosis of prion diseases is based on a positive immunohistochemical reaction (IHR) using antibodies against prion protein (PrP). Unfortunately, this does not distinguish between cellular PrP (PrPC) and the…

In addition to the classical picture of endocapillary proliferative and exudative glomerulonephritis, patients with acute postinfectious glomerulonephritis may manifest a broad spectrum of various histomorphological and immunohistological changes which may reflect the stage of the…

With each somatic cell division, the chromosomal ends, or telomeres, progressively short­en. Critically shortened telomeres are recognised by DNA repair systems as DNA damage, the cells are withdrawn from the…

Histomorphological changes occurring in the liver tissue were studied to confirm the hypothesis about sequential development of primary liver carcinoma. Tumor-surrounding liver tissue was evaluated in 27 cases of hepatocellular…

Proteinopathies are protein deposition diseases caused by misfolded proteins. Molecules of misfolded proteins are prone to aggregate and damage the tissue, and eventually they may kill the patient if a…

Cytopathologic examination is a diagnostic method which encompasses light-microscopic exam­ination of cells that exfoliate spontaneously from body surfaces or are obtained through various diagnostic procedures. Basic diagnostic evaluation of a…

Senile plaques and neurofibrillary tan­gles diagnostically define Alzheimer's disease. Together with dementia they constitute the orig­inal description of this disease, which was formed almost a century ago. But the role…