Extracellular vesicles are a heterogeneous population of membrane vesicles, released from cells both in vivo and in vitro, with an important role in intercellular communication. They have been isolated from…

Tissue engineering as a relatively new field of regenerative medicine has already gone through early developmental stages in a way that it already gives some clinical results. In essence, tissue…

Histamine receptor type 3 was discovered in 1983 by Schwartz and coworkers and cloned in 1999. The expression of histamine receptor type 3 is largely confined to the central nervous…

BACKGROUNDS. Essential arterial hypertension is one of the most common chronic disea­ses of the circulation system. It is often linked to metabolic syndrome with corresponding clinical and biochemical changes of…

Cardiovascular diseases are still the leading cause of morbidity and mortality in the developed world. Besides well-known classical risk factors for atherosclerosis, more and more intention has in recent years…

Endometrial cancer and endometriosis are very common estrogen-dependent diseases. Endometrial cancer is the third most common cancer in women, while endometriosis affects around 15–20% of women of reproductive age and…

Doping involves the use of substances and methods prohibited by international and natio­nal sports institutions. The use of certain substances and methods is harmful to the human body, therefore all…

The object of this study was to determine reference levels of vitamin D and its metabolites in the sera of individuals with normal vitamin D metabolism. The measurements were done…

Oxygen free radicals play an important role in many processes: they are involved in various phases of the inflammatory process and therefore take part in the defence of the organism.…

Oxygen free radicals are obligatory side product of the aerobic cell metabolism. In the first part of the paper their main characteristics and formation paths as well as the reactions…

With the introduction of computer technology in science in the past decade, enzyme kinetics acquired entirely new dimensions. The greatest progress was made in the field of acquisition and subsequent…

The paper surveys the physiological aspects of androgens. It describes in more detail synthesis of C19 steroids, their metabolism and transport, and presents serum salivary levels of individual androgens in…

Unexpected results of laboratory tests may be due to various factors. These include drug effects, which may be either biological, or due to analytical interferences. The more com­mon biological effects…

A family with autosomal dominant cancer was first reported one century ago. The heredi­tary nature of some forms of colorectal cancer was confirmed less than 10 years ago by the…

The article presents some facts about vegetarian diet, its influence on child develop­ment, possible complications and their preven­tion. A vegetarian diet, if properly selected, can meet all the requirements of…

Two polymorphic sites of the CYP1A1 gene, coding for cytochrome P4501A1 enzyme, have been discovered so far. One involves the 7th exon of the coding region; a nucleotide chan­ge leads…

The spread of metastases from a primary site through blood or the lymphatic system, which results in the establishment of secondary tumors in distant locations, is the main cause of…

Acids are donors, while bases are acceptors of protons in solutions. Many various acids and bases are incorporated into organisms by everyday alimentation and cell metabolism, whi­le the output routes…

With each somatic cell division, the chromosomal ends, or telomeres, progressively short­en. Critically shortened telomeres are recognised by DNA repair systems as DNA damage, the cells are withdrawn from the…

Stomach cancer (gastric adenocacinoma) is a common malignant disease in Slovenia. The Lauren's classification distinguishes between a well differentiated intestinal type and a poorly differentiated diffuse type of the disease, which differ in…

Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an…

A two-dimensional gel electrophoresis is one of the basic techniques of proteomics. It is used to separate proteins. As already hinted by the name, we are using the method to…

Benign prostatic hyperplasia is the most common benign neoplasia in men over 60 years of age, while prostate cancer affects 15 to 30% of men between 50 and 70 years…

In the present research we tried to prove, that specific myosin heavy chain is relat­ed to a prevalent metabolic type and that activ­ities of succinate-dehydrogenase and a glycerophosphate dehydrogenase in…