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Archive » 2015 » 1 » | Archive » Medical field » Fields » Biochemistry » Archive » Medical field » Fields » Cell Biology »

The Use of Biocompatible PolyHIPE Acrylates for Bone Tissue Engineering

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Tissue engineering as a relatively new field of regenerative medicine has already gone through early developmental stages in a way that it already gives some clinical results. In essence, tissue engineering includes the use of a combination of cells, engineering, materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. Because bone tissue provides the main mechanical and integrating support to the whole organism and because it also regenerates relatively slowly, it is of great importance to use appropriate inanimate materials during wound healing. The principal component of bone tissue is extracellular matrix which is mechanicaly both firm and flexible but still biologicaly dynamic structure that is synthesized and degraded as a result of extra- and intracellular signaling. Apart from that, it also represents a suitable bioinformational environment for bone cell growth and development. That is why it is necessary for a 3D scaffold to have proper mechanical, chemical, and biological characteristics. Acrylate polymers have already proved as a promising material for 3D scaffold engineering especially in the form of high internal phase emulsion. Their advantages are mainly technological, i.e. simple and adaptable production and reproducibility, but they lack some biological qualities such as suitable bioinformational environment, biodegradability,
and monomere toxicity.

Authors:
Deželak Matjaž, Bavec Aljoša, Knežević Miomir

Keywords:
polyHIPE materials, tissue engineering, bone substitute, bone tissue, 3D scaffolds, pre-clinical studies, regenerative medicine

Cite as:
Med Razgl. 2015; 54 (1): 21–39.

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