BACKGROUNDS. Numerous scientific and clinical findings confirm that pain slows down the process of wound healing. In our previously published research, we presented a prototype of an analgesic wound dressing…

Antipsychotics are a heterogeneous group of drugs with multiple usages. Poisoning with antipsychotics is the eight most common poisoning with drugs affecting the neural system. Due to a high number…

A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected undesirable effects that became apparent only in the post market phase.…

Cannabis has a long history of consumption both for recreational and medicinal uses. After the discovery of endogenous cannabinoid system and cloning of cannabinoid receptors during the last decade of…

Inadvertent doping is defined as an unintentional breach of anti-doping rules, which is often the result of professional errors, negligence or ignorance. Depending on etiology, inadvertent doping can be due…

We present a case of acute acetaminophen intoxication, which is a commonly used analgesic and antipyretic drug. It can be bought over the counter, which makes it widely available. Fast…

Histamine receptor type 3 was discovered in 1983 by Schwartz and coworkers and cloned in 1999. The expression of histamine receptor type 3 is largely confined to the central nervous…

Ethylene glycol intoxications are quite rare. The toxicity of ethylene glycol is largely related to its metabolites rather than the parent compound itself. Our case report represents the typi­cal clinical…

Bipolar disorder is very prevalent in general population. According to Diagnostic and statistical manual of mental disorders, fourth revision – DSM-IV, four types of bipolar disorder are distinguished: bipolar disorder…

In the past medicinal mushrooms have been widely used in Asia, but over the past several years dietary supplements containing medicinal mushrooms have also been introduced on the pharmaceutical and food market…

Amphetamine consumption is highly spread throughout the world, especially in the Unites States of America, Australia and Asia. In Slovenia, the consumption of amphetamines and methamphetamines is not so spread and, further…

The incidence of bronchial asthma is very high in paediatric as well as in the adult population. Nevertheless, life style changes and adequate pharmacotherapy enables asthma patients to live normal,…

Cough is an important disease symptom. Causes of cough are respiratory tract infections, chronic obstructive pulmonary disease, asthma, lung cancer, bronchiectasie, and many other lung diseases, but also smoking, airway…

BACKGROUNDS. Depression is the most common mental disorder and is a serious mental illness. It is a mental disorder that pose a real problem to the public health care system.…

Biological drugs mostly differ from classical agents in their molecular mass, complex three-dimensional structure, molecular heterogeneity and imunogenity. Moreover, the most important aspect of these agents is their capability of…

BACKGROUNDS. Antibiotics are antibacterial agents that are used for empirical, oriented and prophylactic treatment of various infectious diseases. Although the majority of antibiotics is prescribed outside hospitals, hospitals remain foci…

Sex might be an important factor in the development of certain ischemic diseases of the heart. We tried to assess the effects of treating rats with estradiol or testosterone on…

Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants…

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff's rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10…

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff's rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10…

Topical corticosteroids for dermal use are among the most frequently used dermatologicals. Number of available agents of different strength and vehicles is increasing. Along with recent development of high-potency topical…

Biocompatibility of different materials in the body is very complicated phenomenon. Although structural characteristics of implant are decisive for its specific purpose, biologic response mainly depends on surface characteristics of…

Unexpected results of laboratory tests may be due to various factors. These include drug effects, which may be either biological, or due to analytical interferences. The more com­mon biological effects…

Antidepressants are known to influence the kinetics of histamine. The purpose of this study was twofold: to determine the influence of various doses of antidepressants fluvoxamine and mapro­tiline on induced…