The mechanism of action of the actino­porins, substances from the sea anemone Actinia equina, is by cation selective pore formation in the cellular membranes that consequently cause cell lysis. The…

Bioterrorism is an attack on the health of the general population through an artificially induced epidemic of bacterial infectious diseases such as anthrax, plague, cholera, tularemia, brucellosis or botulism, and…

Numerous preclinical and clinical studies have shown a correlation between the consumption of moderate amounts of red wine and a reduced risk of cardiovascular complications asso­ciated with atherosclerosis. Both polyphenolic…

In the article officinal dosage forms of European pharmacopoeia (Ph. Eur. 3rd Ed.) in an abbreviated form are presented. The com­plete translation is published in Formularium slovenicum - Slovenski dodatek…

This article reviews most systems and approaches for delivery of protein drugs and therapeutic genes into the body. Issues in drug delivery are becoming more important as more potent and…

This article describes drugs influencing water and electrolyte excretion, called diuretics. Most of them modify the transport of sodium ions in tubular epithelial cells via different mech­anisms. They are the…

Calcium antagonists constitute a chemically 
and pharmacologically diverse group of drugs. Chemically, at least four major types of calcium antagonists can 
be distinguished; they include phenylalkylamines, dihydropyridines, benzothiazepines and piperazines.…

Isolated perfused Langendorff rat 
hearts were used for comparing effects of the
 calcium antagonist verapamil on the following 
two models of heart injury: local ischemia (ligature of the anterior interventricular…

Simultaneous administration of digoxin and calcium channel blockers results in increased plasma levels of digoxin. One of the possible mechanisms of this interaction could be a changed enteral absorption of…