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Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants modify the pharmacokinetics of exogenous histamine in cats and rats. They decrease elevated histamine concentrations in plasma after an injection of exogenous histamine. Consequently, animals which have not been treated … Preberite več >>

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff’s rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10 μmol/l chloropyramine or 10 μmol/l famotidine was initiated 10 minutes before ischemia and lasted till the end of the experiments. Registered were left ventricular pressure, heart rate, Q, coronary flow … Preberite več >>

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff’s rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10 μmol/L chloropyramine or 10 μmol/L famotidine was initiated 10 minutes before ischemia and lasted till the end of the experiments. Registered were left ventricular pressure, heart rate, Q, coronary flow … Preberite več >>

Biocompatibility of different materials in the body is very complicated phenomenon. Although structural characteristics of implant are decisive for its specific purpose, biologic response mainly depends on surface characteristics of the implant and its interaction with biologic envi­ronment. Nanolayering of the implant to improve biocompatibility presents a recent innovation in this field of research. One method of nanolayering is layer-by-layer … Preberite več >>

Unexpected results of laboratory tests may be due to various factors. These include drug effects, which may be either biological, or due to analytical interferences. The more com­mon biological effects include direct and indirect effect produced by drugs in vivo; in conse­quence laboratory tests yield unexpected, yet correct results. By contrast, the results of tests influenced by the interference … Preberite več >>

Antidepressants are known to influence the kinetics of histamine. The purpose of this study was twofold: to determine the influence of various doses of antidepressants fluvoxamine and mapro­tiline on induced histamine liberation and its further elimination and to find out whether histamine elim­ination is influenced by its redistribution from plas­ma to blood. Rats (n = 24) were pre-treated with two … Preberite več >>

The mechanism of action of the actino­porins, substances from the sea anemone Actinia equina, is by cation selective pore formation in the cellular membranes that consequently cause cell lysis. The aim of the present study was to inves­tigate the mechanism of the toxicity of actinoporin equinatoxin I. In in vivo experiments the measurements of ECG (lead I), respiratory activ­ity … Preberite več >>

Numerous preclinical and clinical studies have shown a correlation between the consumption of moderate amounts of red wine and a reduced risk of cardiovascular complications asso­ciated with atherosclerosis. Both polyphenolic components and ethanol are responsible for the apparent protective effects of red wine, as they influence different biochemical and cellu­lar processes and thus affect the development and progression of atherosclerosis. … Preberite več >>

In the article officinal dosage forms of European pharmacopoeia (Ph. Eur. 3^rd Ed.) in an abbreviated form are presented. The com­plete translation is published in Formularium slovenicum – Slovenski dodatek k evropski far­makopeji. The presented dosage forms are diverse, modern and improved. The require­ments for their quality, safety and efficacy are precisely defined. In Formularium slovenicum the intesively developing … Preberite več >>

Calcium antagonists constitute a chemically 
and pharmacologically diverse group of drugs. Chemically, at least four major types of calcium antagonists can 
be distinguished; they include phenylalkylamines, dihydropyridines, benzothiazepines and piperazines. As a
group they share the common property of slowing the 
transmembrane entry of calcium ions through either 
voltage-activated, or (probably) receptor operated, ion
 selective channels. They differ from one … Preberite več >>

Isolated perfused Langendorff rat 
hearts were used for comparing effects of the
 calcium antagonist verapamil on the following 
two models of heart injury: local ischemia (ligature of the anterior interventricular artery) and
 general hypoxia (perfusate saturated with nitrogen). The degree and extent of injury were
 assessed by measuring the activity of lactate 
dehydrogenase in venous effluents from the 
heart, contractility, … Preberite več >>