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Archive » 2011 » 2 » | Archive » Medical field » Fields » Pathology » Archive » Medical field » Fields » Pathophysiology » Archive » Medical field » Fields » Physiology »

Skeletal Muscle Regeneration – Mechanisms, Satellite Cells, Factors Involved

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Skeletal muscle is the most abundant of the human body’s tissues and it represents a substantial percentage of body mass. Its main function is contraction, which produces force for different types of movement. It also includes the contraction of skeletal muscles that enables locomotion, joint stabilization, posture maintenance and production of body heat. Overall, skeletal muscles play an important role in the body’s long-term survival and are crucial for fast and efficient response to changes in the external environment, as well as for communication and command of the environment. The unique features of skeletal muscle morphology and function reflect its special embryonic development. Skeletal muscles are constantly exposed to metabolic and mechanical injuries, particularly due to the high metabolic rate during contractions. Efficient regeneration is a prerequisite for the maintenance of skeletal muscle mass and function, and it is essentially a recapitulation of embryonic myogenesis. In addition, muscle regeneration is a complex and multistep process which includes intricate direct and indirect cellular and trophic interactions.

Authors:
Marš Tomaž

Keywords:
skeletal muscle, muscle regeneration, satellite cells, trophic factors

Cite as:
Med Razgl. 2011; 50: 179–85.

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