MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2014 » 2 » | Archive » 2014 » 2 » Archive » Medical field » Fields » Histology and Embryology » Archive » Medical field » Fields » Oncology »

Cancer Stem Cells: Key to Improved Treatment of Malignant Melanoma?

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Malignant melanoma is an unpredictable, aggressive disease with the fastest growing incidence among all cancers. Its high metastatic potential and tendency to relapse are poorly prevented by existing systemic therapy. In spite of apparent eradication through treatment in accordance with the newest clinical guidelines, the disease is likely to recur. Cancer stem cells, with their plasticity, self-renewal ability and drug resistance represent a highly probable culprit for these relapses. This special subpopulation of cancer cells is relatively small in number, but harbors uncanny tumor initiating, invasion and metastasis potential. While their very existence remains a controversy among research groups, the evidence for their prominent role in malignancies has multiplied with the number of studies performed in this area in the past few years. Unraveling the molecular mechanisms behind these cells’ unique abilities could lead to novel strategies in the diagnostics and treatment of malignant melanoma. Since the diagnostic value of genetic testing has proven questionable, certain recently discovered biomarkers offer a promising alternative. They may also serve as targets for immunotherapy and reprogramming that could lead to improving patient survival and potentially finally curing this insidious disease.

Authors:
Prunk Tanja, Šalamon Špela

Keywords:
malignant melanoma, stem cells, cancer stem cells, ABCB5, CD271, Sox-10, potential clinical applications

Cite as:
Med Razgl. 2014; 53 (2): 233–44.

Download PDF >>
© 2021 Društvo Medicinski razgledi | Na vrh strani / To top ↑