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A careful clinical examination and patient's medical history contribute to the diagnosis of wrist disease. It is important to obtain disease-related information, accurately inspect and palpate all parts of the wrist and check the range of motion of the wrist. The symptomatic wrist should always be compared with the contralateral wrist. In palpation we pay attention to the presence of pain in specific areas of the wrist. The central dorsal area, lateral (radial), radial volar, ulnar volar and medial (ulnar) areas, and the distal row of carpal bones with bases of metacarpal bones should be palpated. We should precisely palpate individual structures, particularly the bones (scaphoid, lunate, triquetrum, pisiform, trapezium, trapezoid, capitate and hamate) and the tendons (extensors and flexors), and if necessary perform special tests (for example: Finkelstein’s test, Kirk Watson’s test, Linscheid test, Kleinman shear test, hook of the hamate pull test, Allen’s test, Tinel’s test, and Phalen’s test). At the end we must check active and passive range of motion: extension, flexion, radial and ulnar deviation, pronation and supination.