MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 1999 » 1 » | Archive » Medical field » Fields » Cell Biology »

Degradation pathways of cell ingredients

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

The degradation of cell ingredients takes place mainly in lysosomes. The most important and also the best known degradation pathway is autophagy, where a sequestrating membrane separates a part of the cytoplasm so forming an autophagic vacuole. Degradation of the autophagic vacuole ingredients starts after the fusion of the autophagic vacuole with a lysosome. Some cytosolic proteins are introduced to a lysosom by a heat-shock protein (Hsp 70) in a process called carrier mediated proteolysis. Another pathway of lysosomal protein degradation is crinophagy where the secretory vesicles containing newly synthesised proteins fuse with the lysosomal membrane instead of fusing with the plasma membrane. Part of the proteolysis is localised in the cytosol and is known as nonlysosomal proteolysis. In this degradation, large protein complexes proteasomes and protein ubiquitin are involved. The degradation products are reused for the synthesis of new cell components. Thus degradation processes are involved in recycling of the cell ingredients.

Authors:
Veranič Peter, Pšeničnik Majda

Keywords:
lysosomes, autophagocytosis, lysosomal storage diseases

Cite as:
Med Razgl. 1999; 38: 83–90.

Download PDF >>
© 2021 Društvo Medicinski razgledi | Na vrh strani / To top ↑