Spoštovani kupci!
Zaradi prenove spletne strani in prehoda na OJS spletna prodaja trenutno ne dela. Prosim, če sporočite, kaj bi radi kupili, na prodaja@medrazgl.si. Dopišite vaše ime in priimek, naslov ter način plačila (s predračunom, ob povzetju ali z gotovino, če prezvamete gradivo v živo v prostorih uredištva v času uradnih ur).
Hvala za razumevanje!
MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2007 » 1 » | Archive » Medical field » Fields » Internal Medicine »

Early Functional Changes of Left Ventricle in Essencial Arterial Hypertension

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

Essential arterial hypertension is one of the commonest chronic diseases of circulation sys­tem. Before the onset of raised blood pressure, the functional and morphological changes of the left ventricle develop. The aim of the study was to asses functional and possible morphological characteristics of left ventricle with concomitant biochemical parameters in young normotensive individuals with familial trait of hypertension. We searched for relationships between functional and bio­chemical parameters and evaluated eventual independent correlations between them. This cross-sectional study included 76 subjects, 44 in study and 32 in control group. We per­formed clinical examination and took blood for biochemical analysis. Using classical echocar- diographical technique and tissue pulse Doppler echocardiography, we estimated morphological characteristics and diastolic function of the heart. There were differences between study and control group in anthropometric indexes and blood pressure, as well as in some biochemical parameters. Classic echocardiographical inves­tigation revealed changes in morphology and diastolic function of left ventricle. Tissue Doppler echocardiography confirmed differences in relaxation (Em/Am ratio: 1,19 ± 0,35 vs 1,67 ± 0,33, p< 0,001; two-tailed Student’s t-test) and compliance (E/Em: 7,51 ±1,28 vs 6,60±1,02, p = 0,001; two-tailed Student’s t-test) of left ventricle. The groups did not differ in systolic function. In all subjects, relaxation parameters of left ventricle were negatively correlated with positive family history, male gender, higher anthropometric indexes, blood pressure and insulin con­centrations (r = -0,58, p < 0,001; Spearman’s correlation). Multiple regression model analysis revealed independent influence of positive family history, male gender and insulin con­centration on relaxation properties (R2 = 0,51; p< 0,001). We also established correlations between changes in diastolic function and left ventricular mass and enlarged left atrium, on the other hand, there was no correlation with aldosterone concentrations. Study groups differed in parameters, which are a constitutive part of metabolic syndrome. It seems that functional changes of left ventricle are not dependent upon blood pressure; they may even be inherited. The aldosterone concentration was not correlated with diastolic function of left ventricle.

Authors:
Željko Tadej, Trojar Andrej, Žižek Bogomir

Keywords:
hypertension, echocardiography, ventricular dysfunction left

Cite as:
Med Razg. 2007; 46: 3–17.

Download PDF >>
© 2024 Društvo Medicinski razgledi | Na vrh strani / To top ↑