Echocardiography has an established role in evaluation of patients with infective endocarditis. Positive echocardiogram is one of the Duke’s major critera for infective endocarditis. Transthoracic and transesophageal echocardiography can localize the vegetations, demonstrate infective complications such as abscesses, local mycotic aneurysms, or fistulas. The valve dysfunction is assessed by Doppler echocardiography. The sensitivity for detection of endocarditic lesions is much greater by transesophageal than by transthoracic echocardiography. Transesophageal echocardiography is most important in evaluating infective endocarditis in prosthetic valve endocarditis. Echocardiography has an important role in management of patients with infective endocarditis and in decision making about the necessity and timing of surgical intervention.