MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2011 » 3 » | Archive » Medical field » Fields » Pathophysiology » Archive » Medical field » Fields » Physiology »

Endothelial Dysfunction

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Endothelial dysfunction represents one of the earliest changes in arterial function and is an important event in the atherosclerotic process. Reduced production or bioavailability of nitric oxide is the most important in the process of endothelial dysfunction, while on the other hand, it also includes a mismatch between the vasodilators and vasoconstrictors acting on the arte­rial wall. This article describes the role of normal endothelium and nitric oxide, as well as the pathophysiology of endothelial dysfunction. Clinically, endothelial function is assessed by nonin­vasive and invasive methods, listed in the article. The most commonly and widely used clini­cal method is noninvasive ultrasonographic flow mediated dilation measurement. Endothelial dysfunction is a reversible disorder that can be improved by nonpharmacological or phar­macological interventions. Healthy lifestyle is the principal non-pharmacological intervention. Currently the most promising of the pharmacological interventions are the pleiotropic effects of statins and inhibitors of the renin-angiotensin system.

Authors:
Janić Miodrag, Lunder Mojca, Sabovič Mišo

Keywords:
endothelial function, nitric oxide, risk factors, clinical investigation, pharmacological intervention, non-pharmacological intervention

Cite as:
Med Razgl. 2011; 50: 297–305.

Download PDF >>
© 2020 Društvo Medicinski razgledi | Na vrh strani / To top ↑