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Archive » 2010 » 3 » | Archive » Medical field » Fields » Gynecology and Obstetrics »

Estrogens and Endometriosis

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

Endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial glands and stroma outside the uterine cavity. The etiology of endometriosis is multifactorial and includes complex interactions of genetic, immunological, hormonal and environmental factors. There are three different types of endometriosis with different etio­logies and pathogenesis: peritoneal, ovarian, and deep infiltrating endometriosis. This review presents current theories on pathogenesis of endometriosis, followed by an overview on estrogen biosynthesis and action in ectopic endometrium. The role of individual enzy­mes and receptors in estrogen action is discussed and crosstalk between estrogens, inflam­mation and proliferation is explained.

Authors:
Lanišnik Rižner Tea, Ribič - Pucelj Martina

Keywords:
peritoneal endometriosis, ovarian endometriosis, deep infiltrating endometriosis, enzymes of estrogen biosynthesis and metabolism, estrogen receptors

Cite as:
Med Razgl. 2010; 49: 263–74.

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