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Immune interventions were introduced in the treatment of human cancer about 100 years ago. Thanks to the development of monoclonal antibodies and molecular gene technology during the past 15 years, cancer immunotherapy has changed dramatically, making an exeptionally rapid progress. The paper reviews briefly the major advances in cancer immunotherapy, including various immunisation techniques, treatment with cytokines and their analogues, and the use of monoclonal antibodies and immune cells cultured in vitro.