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Streptococcus dysgalactiae subsp. equisimilis (group C/G beta-hemolytic streptococcus) is increasingly being recognized as an important bacterial pathogen in humans. It is part of the normal bacterial microbiota of the human skin, upper respiratory, gastrointestinal and genitourinary tract. Under certain conditions it can cause not only superficial skin and soft tissue infections, but also invasive tissue infections, and even life-threatening streptococcal toxic shock syndrome. Recent studies report that the clinical spectrum of diseases is closely related to Streptococcus pyogenes (group A beta-hemolytic streptococcus) and that the two groups also share many of the virulence factors. The incidence of Streptococcus dysgalactiae subsp. equisimilis infections has been increasing in recent years. Infections occur more often in eldery people with an underlying disease. The group still shows high susceptibility to beta-lactam antibiotics; however, macrolide and tetracycline resistance is increasing. In this paper, we present 14 cases of Streptococcus dysgalactiae subsp. equisimilis infections and a brief literature review.