Apoptosis, named as programmed cell death, represents one form of cell death and has a crucial role in the tissue homeostasis. Besides this, apoptosis is involved in a number of pathological conditions, such as cancer, auto-immune diseases and viral infections. Morphological characteristics of apoptosis are cell shrinkage, nuclear chromatin condensation and formation of apoptotic bodies. Apoptosis is genetically regulated process of cell death with biochemical feature of enzymes activation, involving cleavage of nuclear DNA by endonuclease and responsibility of transglutaminase for formation of apoptotic bodies. In multicellular organisms apoptosis serves as a clean and efficient mechanism for the elimination of unwanted cells, that may have been produced in excess, which have been damaged or whose function is no longer required.