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In the last few decades, remarkable progress has been made in the management of Parkinson’s disease, based mainly on recent discoveries in the fields of pathophysiology and biochemistry. The author briefly outlines biochemical changes occurring in the dopaminergic system in Parkinson’s disease, and describes clinical manifestations of this disease. He stresses the importance of clinical diagnosis and presents errors most commonly made in differential diagnosis. Today, a combined use of levodopa, dopamine agonists and selective MAO-inhibitors seems to be the optimal therapy yet the problem of adverse effects of long-term levodopa administration still remains to be solved. The author acquaints us with the atempts hither made to reduce and eliminate these effects. He emphasizes individual approach to the patients and presents therapeutic measures taken to relieve specific symptoms of patients with Parkinson’s disease.