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Diabetes mellitus can be explained
 pathophysiologically as a disorder impairing 
mechanisms responsible for normoglycemia. In
 the first part of the paper, entitled “Mechanisms
 underlying preservation of normoglycemia” these mechanisms are extensively described. In 
the second part, “Disordered metabolism due 
to the lack of the effects of insulin and consequent complications” pathophysiology of acute 
and chronic complications of diabetes mellitus
 is discussed. The last part “Causes of the lack 
of the insulin effects” deals with pathophysiology of disorders leading to the lack of insulin
 effects.