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Pathophysiological mechanisms of flaccid and spastic paralysis are presented. Characteristic features of flaccid paralysis described in the paper include decreased muscle strength, hypotonia or atonia, depressed or absent proprioceptive reflexes, and muscle wasting. Next, the author presents the following signs of spastic paralysis: decreased muscle strength associated with loss of subtle movements, muscle hypertonia, increased proprioceptive reflexes, decrease in or loss of exteroceptive reflexes and occurrence of pathologic reflexes.